6A70
 
 | | Structure of the human PKD1/PKD2 complex | | Descriptor: | Polycystin-1, Polycystin-2 | | Authors: | Su, Q, Hu, F, Ge, X, Lei, J, Yu, S, Wang, T, Zhou, Q, Mei, C, Shi, Y. | | Deposit date: | 2018-06-29 | | Release date: | 2018-08-15 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the human PKD1-PKD2 complex.
Science, 361, 2018
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7D7E
 | | Structure of PKD1L3-CTD/PKD2L1 in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | | Authors: | Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y. | | Deposit date: | 2020-10-03 | | Release date: | 2021-08-25 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
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7D7F
 | | Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | | Authors: | Su, Q, Shi, Y.G. | | Deposit date: | 2020-10-03 | | Release date: | 2021-09-01 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
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8YWA
 | | The structure of IgE receptor binding to IgE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2024-03-30 | | Release date: | 2024-11-06 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Molecular mechanism of IgE-mediated Fc epsilon RI activation.
Nature, 637, 2025
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8YVU
 | | structure of Ige receptor | | Descriptor: | CHOLESTEROL, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2024-03-29 | | Release date: | 2024-11-06 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Molecular mechanism of IgE-mediated Fc epsilon RI activation.
Nature, 637, 2025
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8ZK4
 | | Local refinemnt of pAg-bound BTN2A1-BTN3A1-BTN3A3 in complex with Vgamma9-Vdelta2 TCR (G115 genotype), another TCR focused | | Descriptor: | Butyrophilin subfamily 2 member A1, T cell receptor delta variable 2,T cell receptor delta constant 1, T cell receptor gamma variable 9,T cell receptor gamma constant 1 | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structures of the full length pAg-bound BTN2A1-BTN3A1-BTN3A3 in complex with Vgamma9-Vdelta2 TCR (G115 genotype) at 3.8 Angstroms resolution
To Be Published
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8ZJZ
 | | Cryo-EM structure of the full-length pAg-bound BTN2A1-BTN3A1-BTN3A3 complex | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZJY
 | | Cryo-EM structure of pAg-bound BTN2A1-BTN3A1-BTN3A3 in complex with Vgamma9-Vdelta2 TCR (G115 genotype) | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZK0
 | | Cryo-EM structure of the full length pAg-bound BTN2A1-BTN3A1-BTN3A2 in complex with Vgamma9-Vdelta2 TCR (G115 genotype) | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZHR
 | | Cryo-EM structure of the full-length pAg-bound BTN2A1-BTN3A1-BTN3A2 complex | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-11 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZK1
 | | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A2 mutant complex (BTN3A1 H381R, BTN2A1 R477A/T510A) | | Descriptor: | Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, Butyrophilin subfamily 3 member A2 | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZJX
 | | Cryo-EM structure of the full length pAg-bound BTN2A1-BTN3A1-BTN3A2 in complex with Vgamma9-Vdelta2 TCR (MOP genotype) | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8ZK3
 | | Cryo-EM structure of pAg-bound BTN2A1-BTN3A1-BTN3A2 in complex with Vgamma9-Vdelta2 TCR (G115 genotype), another TCR focused | | Descriptor: | Butyrophilin subfamily 2 member A1, T cell receptor delta variable 2,T cell receptor delta constant 1, T cell receptor gamma variable 9,T cell receptor gamma constant 1 | | Authors: | Xin, W, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2024-05-15 | | Release date: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates gamma delta T Cells
Biorxiv, 2025
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8WY0
 | | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-30 | | Release date: | 2024-05-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | Descriptor: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-31 | | Release date: | 2024-05-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8WXE
 | | Vgamma5Vdelta1 EH TCR-CD3 complex | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-28 | | Release date: | 2024-05-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8YC0
 | | T cell receptor V delta2 V gamma9 in GDN | | Descriptor: | CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2024-02-17 | | Release date: | 2024-05-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (4.12 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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7XQ8
 | | Structure of human B-cell antigen receptor of the IgM isotype | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2022-05-07 | | Release date: | 2022-08-17 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of the human IgM B cell receptor.
Science, 377, 2022
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9L0M
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8JCB
 | | Vgamma5 Vdelta1 T cell receptor complex | | Descriptor: | T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-05-10 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8JBV
 | | Extracellular domain of gamma delta TCR | | Descriptor: | T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1 | | Authors: | Xin, W, Chi, X, Huang, B, Su, Q, Zhou, Q. | | Deposit date: | 2023-05-09 | | Release date: | 2024-05-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8JC0
 | | V gamma9 V delta2 TCR and CD3 complex in LMNG | | Descriptor: | CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-05-10 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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6M22
 | | KCC3 bound with DIOA | | Descriptor: | 2-[[(2~{R})-2-butyl-6,7-bis(chloranyl)-2-cyclopentyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chi, X.M, Li, X.R, Chen, Y, Zhang, Y.Y, Su, Q, Zhou, Q. | | Deposit date: | 2020-02-26 | | Release date: | 2020-11-04 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
Cell Res., 31, 2021
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6M1Y
 | | The overall structure of KCC3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Chi, X.M, Li, X.R, Chen, Y, Zhang, Y.Y, Su, Q, Zhou, Q. | | Deposit date: | 2020-02-26 | | Release date: | 2020-11-04 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
Cell Res., 31, 2021
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8Z6B
 | | Structure of Polycystin-1/Polycystin-2 complex | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-1, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2024-04-18 | | Release date: | 2025-04-23 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of polycystin1/2 complex
To Be Published
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