6XR1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xr1 by Molmil](/molmil-images/mine/6xr1) | |
1M5X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1m5x by Molmil](/molmil-images/mine/1m5x) | Crystal structure of the homing endonuclease I-MsoI bound to its DNA substrate | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | 著者 | Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. | 登録日 | 2002-07-10 | 公開日 | 2003-06-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
|
|
5JSN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jsn by Molmil](/molmil-images/mine/5jsn) | Bcl2-inhibitor complex | 分子名称: | Apoptosis regulator Bcl-2, Bcl2 inhibitor | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2016-05-09 | 公開日 | 2016-11-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
|
|
3KO2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ko2 by Molmil](/molmil-images/mine/3ko2) | I-MsoI re-designed for altered DNA cleavage specificity (-7C) | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | 著者 | Taylor, G.K, Stoddard, B.L. | 登録日 | 2009-11-13 | 公開日 | 2010-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res., 38, 2010
|
|
3LDY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ldy by Molmil](/molmil-images/mine/3ldy) | An extraordinary mechanism of DNA perturbation exhibited by the rare-cutting HNH restriction endonuclease PacI | 分子名称: | CALCIUM ION, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*A)-3'), DNA (5'-D(P*AP*TP*TP*AP*AP*GP*CP*CP*TP*C)-3'), ... | 著者 | Shen, B.W, Heiter, D, Chan, S.-H, Xu, S.-Y, Wilson, G, Stoddard, B.L. | 登録日 | 2010-01-13 | 公開日 | 2010-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure, 18, 2010
|
|
7UNJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7unj by Molmil](/molmil-images/mine/7unj) | De novo designed chlorophyll dimer protein with Zn pheophorbide a methyl ester matching geometry of purple bacterial special pair, SP1-ZnPPaM | 分子名称: | 1,2-ETHANEDIOL, SP1-ZnPPaM designed chlorophyll dimer protein, SULFATE ION, ... | 著者 | Kennedy, M.A, Stoddard, B.L, Ennist, N.M. | 登録日 | 2022-04-11 | 公開日 | 2023-04-19 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat.Chem.Biol., 2024
|
|
7UNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7unh by Molmil](/molmil-images/mine/7unh) | |
7UNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uni by Molmil](/molmil-images/mine/7uni) | De novo designed chlorophyll dimer protein with Zn pheophorbide a methyl ester, SP2-ZnPPaM | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, SP2-ZnPPaM designed chlorophyll dimer protein, ... | 著者 | Kennedy, M.A, Stoddard, B.L, Ennist, N.M. | 登録日 | 2022-04-11 | 公開日 | 2023-04-19 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat.Chem.Biol., 2024
|
|
3UGM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ugm by Molmil](/molmil-images/mine/3ugm) | Structure of TAL effector PthXo1 bound to its DNA target | 分子名称: | DNA-1, DNA-2, TAL effector AvrBs3/PthA | 著者 | Mak, A.N.S, Bradley, P, Cernadas, R.A, Bogdanove, A.J, Stoddard, B.L. | 登録日 | 2011-11-02 | 公開日 | 2012-01-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target. Science, 335, 2012
|
|
4YHX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yhx by Molmil](/molmil-images/mine/4yhx) | |
4Z20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z20 by Molmil](/molmil-images/mine/4z20) | |
4Z1Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z1z by Molmil](/molmil-images/mine/4z1z) | |
4YXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yxx by Molmil](/molmil-images/mine/4yxx) | |
4YXY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yxy by Molmil](/molmil-images/mine/4yxy) | |
6EG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eg7 by Molmil](/molmil-images/mine/6eg7) | BbvCI B2 dimer with I3C clusters | 分子名称: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, BbvCI endonuclease subunit 2, ... | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2018-08-19 | 公開日 | 2018-11-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI. Nucleic Acids Res., 47, 2019
|
|
2ERH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2erh by Molmil](/molmil-images/mine/2erh) | Crystal Structure of the E7_G/Im7_G complex; a designed interface between the colicin E7 DNAse and the Im7 immunity protein | 分子名称: | Colicin E7, Colicin E7 immunity protein | 著者 | Joachimiak, L.A, Kortemme, T, Stoddard, B.L, Baker, D. | 登録日 | 2005-10-24 | 公開日 | 2006-07-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface. J.Mol.Biol., 361, 2006
|
|
2EX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ex5 by Molmil](/molmil-images/mine/2ex5) | |
2FLD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fld by Molmil](/molmil-images/mine/2fld) | I-MsoI Re-Designed for Altered DNA Cleavage Specificity | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | 著者 | Ashworth, J, Duarte, C.M, Havranek, J.J, Sussman, D, Monnat, R.J, Stoddard, B.L, Baker, D. | 登録日 | 2006-01-05 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Computational redesign of endonuclease DNA binding and cleavage specificity. Nature, 441, 2006
|
|
2QOJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qoj by Molmil](/molmil-images/mine/2qoj) | Coevolution of a homing endonuclease and its host target sequence | 分子名称: | I-AniI DNA target seq1, I-AniI DNA target seq2, LAGLIDADG endonuclease, ... | 著者 | Scalley-Kim, M, McConnell Smith, A, Stoddard, B.L. | 登録日 | 2007-07-20 | 公開日 | 2008-11-11 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Coevolution of a homing endonuclease and its host target sequence. J.Mol.Biol., 372, 2007
|
|
4YIT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yit by Molmil](/molmil-images/mine/4yit) | |
4YIS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yis by Molmil](/molmil-images/mine/4yis) | Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ... | 著者 | Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. | 登録日 | 2015-03-02 | 公開日 | 2016-03-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
|
|
6OHH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ohh by Molmil](/molmil-images/mine/6ohh) | Structure of EF1p2_mFAP2b bound to DFHBI | 分子名称: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, CALCIUM ION, EF1p2_mFAP2b | 著者 | Doyle, L.A, Stoddard, B.L. | 登録日 | 2019-04-05 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Incorporation of sensing modalities into de novo designed fluorescence-activating proteins Nat Commun, 12, 2021
|
|
7RDR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rdr by Molmil](/molmil-images/mine/7rdr) | |
7R9G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7r9g by Molmil](/molmil-images/mine/7r9g) | Catalytically inactive yeast Pseudouridine Synthase, PUS1, bound to RNA | 分子名称: | CHLORIDE ION, RNA (5'-R(*AP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3'), SULFATE ION, ... | 著者 | Doyle, L.A, Stoddard, B.L. | 登録日 | 2021-06-29 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1. Plos One, 18, 2023
|
|
7R9F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7r9f by Molmil](/molmil-images/mine/7r9f) | |