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PDB: 20 件
2HDB
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BU of 2hdb by Molmil
HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HMG-CoA synthase, SULFATE ION
著者Steussy, C.N, Sutherlin, A, Stauffacher, C.V.
登録日2006-06-20
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006
1JM6
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Pyruvate dehydrogenase kinase, isozyme 2, containing ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pyruvate dehydrogenase kinase, ...
著者Steussy, C.N, Popov, K.M, Bowker-Kinley, M.M, Sloan, R.B, Harris, R.A, Hamilton, J.A.
登録日2001-07-17
公開日2001-10-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase.
J.Biol.Chem., 276, 2001
1X9E
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Crystal structure of HMG-CoA synthase from Enterococcus faecalis
分子名称: HMG-CoA synthase, SULFATE ION
著者Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
登録日2004-08-20
公開日2005-11-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
1YSL
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Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand.
分子名称: ACETOACETIC ACID, COENZYME A, GLYCEROL, ...
著者Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
登録日2005-02-08
公開日2005-11-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
4I56
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HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa
分子名称: (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
著者Steussy, C.N, Stauffacher, C.V, Schmidt, T, Crichelow, C.J, Rodwell, V.W, Wrensford, L.V, Min, J, Burgner II, J.W.
登録日2012-11-28
公開日2013-07-17
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I64
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3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure
分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
著者Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
登録日2012-11-29
公開日2013-07-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6A
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3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
著者Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
登録日2012-11-29
公開日2013-07-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6W
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3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate
分子名称: (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
著者Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
登録日2012-11-30
公開日2013-07-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6Y
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3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate
分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
著者Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
登録日2012-11-30
公開日2013-07-17
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
7M1Z
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Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
分子名称: (R)-MEVALONATE, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ACETATE ION, ...
著者Bose, S, Steussy, C.N, Stauffacher, C.V.
登録日2021-03-15
公開日2022-09-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
Nat Commun, 2023
8GDN
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Structure of PmHMGR bound to mevalonate, CoA and NAD.
分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ...
著者Purohit, V, Steussy, C.N, Stauffacher, C.V.
登録日2023-03-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
8SZ6
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PmHMGR bound to mevaldehyde and CoA
分子名称: (3R)-3,5,5-trihydroxy-3-methylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Mevaldyl-Coenzyme A, ...
著者Purohit, V, Stauffacher, C.V, Steussy, C.N.
登録日2023-05-27
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
8VLQ
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BU of 8vlq by Molmil
Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9
分子名称: (R)-MEVALONATE, (R)-mevaldehyde, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
著者Purohit, V, Steussy, C.N, Stauffacher, C.V.
登録日2024-01-12
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys.J., 123, 2024
5JNP
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BU of 5jnp by Molmil
Crystal structure of a rice (Oryza Sativa) cellulose synthase plant conserved region (P-CR)
分子名称: CITRATE ANION, GLYCEROL, PHOSPHATE ION, ...
著者Rushton, P.S, Olek, A.T, Makowski, L, Badger, J, Steussy, C.N, Carpita, N.C, Stauffacher, C.V.
登録日2016-04-30
公開日2016-12-28
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.404 Å)
主引用文献Rice Cellulose SynthaseA8 Plant-Conserved Region Is a Coiled-Coil at the Catalytic Core Entrance.
Plant Physiol., 173, 2017
2PNR
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BU of 2pnr by Molmil
Crystal Structure of the asymmetric Pdk3-l2 Complex
分子名称: DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3
著者Vassylyev, D.G, Steussy, C.N, Devedjiev, Y.
登録日2007-04-25
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of an Asymmetric complex of Pyruvate Dehydrogenase Kinase 3 with Lipoyl domain 2 and its Biological Implications
J.Mol.Biol., 370, 2007
7M3H
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Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
分子名称: 5-[(4-butylphenyl)sulfamoyl]-2-hydroxybenzoic acid, CALCIUM ION, Hydroxymethylglutaryl-CoA reductase, ...
著者Bose, S, Steussy, C.N, Stauffacher, C.V.
登録日2021-03-18
公開日2022-09-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
To Be Published
7M66
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Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Bose, S, Steussy, C.N.
登録日2021-03-25
公開日2022-09-28
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor.
Commun Biol, 6, 2023
1R7I
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BU of 1r7i by Molmil
HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.
分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION
著者Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
登録日2003-10-21
公開日2003-11-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
1R31
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HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA
分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ...
著者Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
登録日2003-09-30
公開日2003-10-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
4I4B
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HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA
分子名称: (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ...
著者Stauffacher, C.V, Steussy, C.N, Critchelow, C.J, Schmidt, T, Min, J, Wrensford, L.V, Burgner, J.W, Rodwell, V.W.
登録日2012-11-27
公開日2013-07-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013

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