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PDB: 349 件
3UTZ
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BU of 3utz by Molmil
Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential
分子名称: Metalloproteinase, heavy chain, light chain, ...
著者Sela-Passwell, N, Kikkeri, R, Dym, O, Rozenberg, H, Margalit, R, Arad-Yellin, R, Eisenstein, M, Brenner, O, Shoham, T, Danon, T, Shanzer, A, Sagi, I, Israel Structural Proteomics Center (ISPC)
登録日2011-11-27
公開日2011-12-14
最終更新日2017-03-15
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.
NAT.MED. (N.Y.), 18, 2012
4IIJ
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BU of 4iij by Molmil
Crystal structure of tubulin-stathmin-TTL-apo complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Prota, A.E, Magiera, M.M, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, C.C, Kammerer, R.A, Janke, C, Steinmetz, M.O.
登録日2012-12-20
公開日2013-01-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
2HKQ
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BU of 2hkq by Molmil
Crystal structure of the C-terminal domain of human EB1 in complex with the CAP-Gly domain of human Dynactin-1 (p150-Glued)
分子名称: Dynactin-1, Microtubule-associated protein RP/EB family member 1
著者Honnappa, S, Winkler, F.K, Steinmetz, M.O.
登録日2006-07-05
公開日2006-09-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Key interaction modes of dynamic +TIP networks.
Mol.Cell, 23, 2006
6FJM
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BU of 6fjm by Molmil
tubulin-Disorazole Z complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Disorazole Z, ...
著者Menchon, G, Prota, A.E, Lucena Agell, D, Bucher, P, Jansen, R, Irschik, H, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
登録日2018-01-22
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
7UHY
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BU of 7uhy by Molmil
Human GATOR2 complex
分子名称: GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ...
著者Rogala, K.B, Valenstein, M.L, Lalgudi, P.V.
登録日2022-03-27
公開日2022-07-20
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.66 Å)
主引用文献Structure of the nutrient-sensing hub GATOR2.
Nature, 607, 2022
6FLK
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BU of 6flk by Molmil
Crystal structure of Cep120 C2C domain
分子名称: Cep120
著者Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
登録日2018-01-26
公開日2018-02-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
1VT7
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BU of 1vt7 by Molmil
Structures of the mismatched duplex D(GGGTGCCC)
分子名称: DNA (5'-D(*GP*GP*GP*TP*GP*CP*CP*C)-3')
著者Rabinovich, D, Haran, T, Eisenstein, M, Shakked, Z.
登録日1996-12-02
公開日2011-07-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of the mismatched duplex d(GGGTGCCC) and one of its Watson-Crick analogues d(GGGCGCCC).
J.Mol.Biol., 200, 1988
6FII
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BU of 6fii by Molmil
Tubulin-Spongistatin complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
登録日2018-01-18
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FLJ
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BU of 6flj by Molmil
Crystal structure of Cep120 C2A_K76A mutant
分子名称: Centrosomal protein of 120 kDa
著者Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
登録日2018-01-26
公開日2018-02-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
6FJF
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BU of 6fjf by Molmil
Tubulin-FcMaytansine complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
登録日2018-01-22
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
3L3S
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BU of 3l3s by Molmil
Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi
分子名称: Enoyl-CoA hydratase/isomerase family protein
著者Eswaramoorthy, S, Silberstein, M, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-12-17
公開日2010-01-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi
To be Published
4I55
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BU of 4i55 by Molmil
Crystal structure of tubulin-stathmin-TTL complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Prota, A.E, Bargsten, K, Zurwerra, D, Field, J.J, Diaz, J.F, Altmann, K.H, Steinmetz, M.O.
登録日2012-11-28
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
1USX
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BU of 1usx by Molmil
Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN, N-acetyl-alpha-neuraminic acid-(2-6)-methyl 6-thio-beta-D-galactopyranoside
著者Zaitsev, V, Itzstein, M, Groves, D, Kiefel, M, Takimoto, T, Portner, A, Taylor, G.
登録日2003-12-01
公開日2004-03-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
J.Virol., 78, 2004
4J4A
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BU of 4j4a by Molmil
Crystal Structure of Engineered Trimeric Cortexillin-1 Coiled-Coil Variant
分子名称: Cortexillin-1, PHOSPHATE ION
著者Bjelic, S, Steinmetz, M.O, Kammerer, R.A.
登録日2013-02-06
公開日2013-05-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6499 Å)
主引用文献Structural basis for the oligomerization-state switch from a dimer to a trimer of an engineered cortexillin-1 coiled-coil variant.
Plos One, 8, 2013
2PTA
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BU of 2pta by Molmil
PANDINUS TOXIN K-A (PITX-KA) FROM PANDINUS IMPERATOR, NMR, 20 STRUCTURES
分子名称: PANDINUS TOXIN K-ALPHA
著者Tenenholz, T.C, Rogowski, R.S, Collins, J.H, Blaustein, M.P, Weber, D.J.
登録日1996-11-26
公開日1997-12-10
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels.
Biochemistry, 36, 1997
3GJP
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BU of 3gjp by Molmil
Crystal structure of mutant coiled coil GCN4 leucine zipper
分子名称: General control protein GCN4
著者Honnappa, S, Steinmetz, M.O.
登録日2009-03-09
公開日2010-03-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
2O7H
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BU of 2o7h by Molmil
Crystal structure of trimeric coiled coil GCN4 leucine zipper
分子名称: General control protein GCN4
著者Jawhari, H, Honnappa, S, Steinmetz, M.O.
登録日2006-12-11
公開日2007-11-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
1USR
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BU of 1usr by Molmil
Newcastle disease virus hemagglutinin-neuraminidase: Evidence for a second sialic acid binding site and implications for fusion
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-alpha-D-glucopyranose, CALCIUM ION, ...
著者Zaitsev, V, Von Itzstein, M, Groves, D, Kiefel, M, Takimoto, T, Portner, A, Taylor, G.
登録日2003-11-28
公開日2004-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
J.Virol., 78, 2004
2PZI
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BU of 2pzi by Molmil
Crystal Structure of Protein kinase PknG from Mycobacterium tuberculosis in Complex with Tetrahydrobenzothiophene AX20017
分子名称: 2-[(CYCLOPROPYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, CADMIUM ION, CHLORIDE ION, ...
著者Honnappa, S, Steinmetz, M.O.
登録日2007-05-18
公開日2007-07-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4I50
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BU of 4i50 by Molmil
Crystal structure of tubulin-stathmin-TTL-Epothilone A complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Prota, A.E, Bargsten, K, Zurwerra, D, Field, J.J, Diaz, J.F, Altmann, K.H, Steinmetz, M.O.
登録日2012-11-28
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
1FVV
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BU of 1fvv by Molmil
THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
分子名称: 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2
著者Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K.
登録日2000-09-20
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
2L56
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BU of 2l56 by Molmil
NMR structure of the GCN4 trigger peptide refined using biased molecular dynamics simulations
分子名称: General control protein GCN4
著者Missimer, J.H, Dolenc, J, Steinmetz, M.O, van Gunsteren, W.F.
登録日2010-10-26
公開日2010-12-01
最終更新日2011-10-26
実験手法SOLUTION NMR
主引用文献Exploring the trigger sequence of the GCN4 coiled-coil: Biased molecular dynamics resolves apparent inconsistencies in NMR measurements
Protein Sci., 19, 2010
4IHJ
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BU of 4ihj by Molmil
Crystal structure of tubulin-stathmin-TTL-ADP complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
著者Prota, A.E, Magiera, M.M, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, C.C, Kammerer, R.A, Janke, C, Steinmetz, M.O.
登録日2012-12-18
公開日2013-02-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
1FVT
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THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR
分子名称: 4-[(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]benzene-1-sulfonamide, CELL DIVISION PROTEIN KINASE 2
著者Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K.
登録日2000-09-20
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
1WU9
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BU of 1wu9 by Molmil
Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)
分子名称: Microtubule-associated protein RP/EB family member 1
著者Honnappa, S, John, C.M, Kostrewa, D, Winkler, F.K, Steinmetz, M.O.
登録日2004-12-02
公開日2005-02-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural insights into the EB1-APC interaction
Embo J., 24, 2005

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