5IZ2
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![BU of 5iz2 by Molmil](/molmil-images/mine/5iz2) | Crystal structure of the N. clavipes spidroin NTD at pH 6.5 | Descriptor: | Major ampullate spidroin 1A, Major ampullate spidroin 1A (Partial C-terminus) | Authors: | Atkison, J.H, Olsen, S.K. | Deposit date: | 2016-03-24 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Crystal Structure of the Nephila clavipes Major Ampullate Spidroin 1A N-terminal Domain Reveals Plasticity at the Dimer Interface. J.Biol.Chem., 291, 2016
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3MP9
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![BU of 3mp9 by Molmil](/molmil-images/mine/3mp9) | Structure of Streptococcal protein G B1 domain at pH 3.0 | Descriptor: | FORMIC ACID, Immunoglobulin G-binding protein G | Authors: | Tomlinson, J.H, Green, V.L, Baker, P.J, Williamson, M.P. | Deposit date: | 2010-04-26 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural origins of pH-dependent chemical shifts in the B1 domain of protein G. Proteins, 78, 2010
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2MZW
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![BU of 2mzw by Molmil](/molmil-images/mine/2mzw) | Staphylococcus aureus FusB:EF-GC3 complex | Descriptor: | Elongation factor G, Far1, ZINC ION | Authors: | Tomlinson, J.H, Thompson, G.S, Kalverda, A.P, Zhuravleva, A, O'Neill, A. | Deposit date: | 2015-02-25 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance. Sci Rep, 6, 2016
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4K86
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4K87
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![BU of 4k87 by Molmil](/molmil-images/mine/4k87) | Crystal structure of human prolyl-tRNA synthetase (substrate bound form) | Descriptor: | ADENOSINE, PROLINE, Proline--tRNA ligase, ... | Authors: | Hwang, K.Y, Son, J.H, Lee, E.H. | Deposit date: | 2013-04-18 | Release date: | 2013-10-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69, 2013
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4K88
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![BU of 4k88 by Molmil](/molmil-images/mine/4k88) | Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Proline--tRNA ligase, ZINC ION | Authors: | Hwang, K.Y, Son, J.H, Lee, E.H. | Deposit date: | 2013-04-18 | Release date: | 2013-10-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.619 Å) | Cite: | Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69, 2013
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1XM2
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![BU of 1xm2 by Molmil](/molmil-images/mine/1xm2) | Crystal structure of Human PRL-1 | Descriptor: | SULFATE ION, Tyrosine Phosphatase | Authors: | Jeong, D.G, Kim, S.J, Kim, J.H, Son, J.H, Ryu, S.E. | Deposit date: | 2004-10-01 | Release date: | 2005-01-25 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms J.Mol.Biol., 345, 2005
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1ZZW
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![BU of 1zzw by Molmil](/molmil-images/mine/1zzw) | Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 | Descriptor: | 1,2-ETHANEDIOL, Dual specificity protein phosphatase 10, SULFATE ION | Authors: | Jeong, D.G, Yoon, T.S, Kim, J.H, Shim, M.Y, Jeong, S.K, Son, J.H, Ryu, S.E, Kim, S.J. | Deposit date: | 2005-06-14 | Release date: | 2006-07-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of the Catalytic Domain of Human MAP Kinase Phosphatase 5: Structural Insight into Constitutively Active Phosphatase. J.Mol.Biol., 360, 2006
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1YZ4
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![BU of 1yz4 by Molmil](/molmil-images/mine/1yz4) | Crystal structure of DUSP15 | Descriptor: | SULFATE ION, dual specificity phosphatase-like 15 isoform a, octyl beta-D-glucopyranoside | Authors: | Kim, S.J, Ryu, S.E, Jeong, D.G, Yoon, T.S, Kim, J.H, Cho, Y.H, Jeong, S.K, Lee, J.W, Son, J.H. | Deposit date: | 2005-02-28 | Release date: | 2005-11-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase Proteins, 61, 2005
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1UC7
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![BU of 1uc7 by Molmil](/molmil-images/mine/1uc7) | Crystal structure of DsbDgamma | Descriptor: | Thiol:disulfide interchange protein dsbD | Authors: | Kim, J.H, Kim, S.J, Jeong, D.G, Son, J.H, Ryu, S.E. | Deposit date: | 2003-04-09 | Release date: | 2004-04-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of DsbDgamma reveals the mechanism of redox potential shift and substrate specificity(1) FEBS LETT., 543, 2003
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1KR3
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![BU of 1kr3 by Molmil](/molmil-images/mine/1kr3) | Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050. | Descriptor: | 7,8-DIHYDROXY-1-METHOXY-3-METHYL-10-OXO-4,10-DIHYDRO-1H,3H-PYRANO[4,3-B]CHROMENE-9-CARBOXYLIC ACID, SODIUM ION, ZINC ION, ... | Authors: | Payne, D.J, Hueso-Rodrguez, J.A, Boyd, H, Concha, N.O, Janson, C.A, Gilpin, M, Bateson, J.H, Cheever, C, Niconovich, N.L, Pearson, S, Rittenhouse, S, Tew, D, Dez, E, Prez, P, de la Fuente, J, Rees, M, Rivera-Sagredo, A. | Deposit date: | 2002-01-08 | Release date: | 2003-01-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases ANTIMICROB.AGENTS CHEMOTHER., 46, 2002
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5IBY
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5KXA
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![BU of 5kxa by Molmil](/molmil-images/mine/5kxa) | Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[6-chloranyl-2-cyclopropyl-1-(1-ethylpyrazol-4-yl)-7-fluoranyl-indol-3-yl]sulfanyl-2-fluoranyl-benzoic acid, CALCIUM ION, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2016-07-20 | Release date: | 2016-11-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J. Pharmacol. Exp. Ther., 360, 2017
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3U66
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![BU of 3u66 by Molmil](/molmil-images/mine/3u66) | Crystal structure of T6SS SciP/TssL from Escherichia Coli Enteroaggregative 042 | Descriptor: | GLYCEROL, Putative type VI secretion protein | Authors: | Durand, E, Aschtgen, M.S, Zoued, A, Spinelli, S, Watson, P.J.H, Cambillau, C, Cascales, E. | Deposit date: | 2011-10-12 | Release date: | 2012-03-07 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J.Biol.Chem., 287, 2012
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4ZGA
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![BU of 4zga by Molmil](/molmil-images/mine/4zga) | Structural basis for inhibition of human autotaxin by four novel compounds | Descriptor: | (11aS)-6-(4-fluorobenzyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2015-04-22 | Release date: | 2015-10-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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4ZG7
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![BU of 4zg7 by Molmil](/molmil-images/mine/4zg7) | Structural basis for inhibition of human autotaxin by four novel compounds | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-({6-chloro-7-fluoro-2-methyl-1-[2-oxo-2-(spiro[cyclopropane-1,3'-indol]-1'(2'H)-yl)ethyl]-1H-indol-3-yl}sulfanyl)-2-fluorobenzoic acid, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2015-04-22 | Release date: | 2015-10-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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4ZG9
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![BU of 4zg9 by Molmil](/molmil-images/mine/4zg9) | Structural basis for inhibition of human autotaxin by four novel compounds | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(11aS)-6-(4-fluorobenzyl)-1,3-dioxo-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-2(3H)-yl]propanoic acid, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2015-04-22 | Release date: | 2015-10-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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4ZG6
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![BU of 4zg6 by Molmil](/molmil-images/mine/4zg6) | Structural basis for inhibition of human autotaxin by four novel compounds | Descriptor: | 4-{(Z)-2-[6-chloro-1-(4-fluorobenzyl)-1H-indol-3-yl]-1-cyanoethenyl}benzoic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2015-04-22 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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5IDH
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![BU of 5idh by Molmil](/molmil-images/mine/5idh) | |
5ICH
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![BU of 5ich by Molmil](/molmil-images/mine/5ich) | |
5ICL
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![BU of 5icl by Molmil](/molmil-images/mine/5icl) | |
4LKM
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![BU of 4lkm by Molmil](/molmil-images/mine/4lkm) | Crystal structure of Plk1 Polo-box domain in complex with PL-74 | Descriptor: | GLYCEROL, PL-74, SULFATE ION, ... | Authors: | Lee, W.C, Song, J.H, Kim, H.Y. | Deposit date: | 2013-07-08 | Release date: | 2013-12-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1 Plos One, 8, 2013
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4LKL
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4RCP
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![BU of 4rcp by Molmil](/molmil-images/mine/4rcp) | Crystal structure of Plk1 Polo-box domain in complex with PL-2 | Descriptor: | 1,2-ETHANEDIOL, PL-2, Serine/threonine-protein kinase PLK1 | Authors: | Lee, W.C, Song, J.H, Kim, H.Y. | Deposit date: | 2014-09-16 | Release date: | 2014-11-12 | Last modified: | 2015-01-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58, 2015
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1Y6B
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![BU of 1y6b by Molmil](/molmil-images/mine/1y6b) | Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | Descriptor: | N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE, Vascular endothelial growth factor receptor 2 | Authors: | Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. | Deposit date: | 2004-12-05 | Release date: | 2005-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005
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