5KXA

Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis

Summary for 5KXA

• Entry DOI: 10.2210/pdb5kxa/pdb
• Related: 4ZG6 4ZG7 4ZG9 4ZGA
• Descriptor: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total)
• Functional Keywords: enpp2, autotaxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q13822
• Total number of polymer chains: 1
• Total formula weight: 100003.58

Authors

Stein, A.J.,Bain, G.,Hutchinson, J.H.,Evans, J.F. (deposition date: 2016-07-20, release date: 2016-11-09, Last modification date: 2023-10-04)

• Primary citation: Bain, G.,Shannon, K.E.,Huang, F.,Darlington, J.,Goulet, L.,Prodanovich, P.,Ma, G.L.,Santini, A.M.,Stein, A.J.,Lonergan, D.,King, C.D.,Calderon, I.,Lai, A.,Hutchinson, J.H.,Evans, J.F.; Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.; J. Pharmacol. Exp. Ther., 360:1-13, 2017; PubMed: 27754931; DOI: 10.1124/jpet.116.237156

Experimental method

X-RAY DIFFRACTION (2.59 Å)