5KXA
Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | polymer | 863 | 99042.6 | 1 | UniProt (Q13822) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) | Homo sapiens (Human) | E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD |
| 2 | B (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | F (A) | 3-[6-chloranyl-2-cyclopropyl-1-(1-ethylpyrazol-4-yl)-7-fluoranyl-indol-3-yl]sulfanyl-2-fluoranyl-benzoic acid | non-polymer | 473.9 | 1 | Chemie (6Y7) | |||
| 6 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | H (A) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 1 - 863 (UniProt: Q13822)
| PDB | External Database | Details |
|---|---|---|
| Ala 54 | Asn 54 | engineered mutation |
| Ala 411 | Asn 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 99042.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 961.0 | |
| All* | Total formula weight | 100003.6 |
