4ZGA
Structural basis for inhibition of human autotaxin by four novel compounds
Summary for 4ZGA
Entry DOI | 10.2210/pdb4zga/pdb |
Related | 4ZG6 4ZG7 4ZG9 |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (9 entities in total) |
Functional Keywords | autotaxin, enpp2, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : Q13822 |
Total number of polymer chains | 1 |
Total formula weight | 100530.65 |
Authors | Stein, A.J.,Bain, G.,Hutchinson, J.H.,Evans, J.F. (deposition date: 2015-04-22, release date: 2015-10-14, Last modification date: 2020-07-29) |
Primary citation | Stein, A.J.,Bain, G.,Prodanovich, P.,Santini, A.M.,Darlington, J.,Stelzer, N.M.,Sidhu, R.S.,Schaub, J.,Goulet, L.,Lonergan, D.,Calderon, I.,Evans, J.F.,Hutchinson, J.H. Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88:982-992, 2015 Cited by PubMed: 26371182DOI: 10.1124/mol.115.100404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report