4ZG9

Structural basis for inhibition of human autotaxin by four novel compounds

Summary for 4ZG9

Entry DOI	10.2210/pdb4zg9/pdb
Related	4ZG6 4ZG7 4ZGA
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	autotaxin, enpp2, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted : Q13822
Total number of polymer chains	2
Total formula weight	201573.83
Authors	Stein, A.J.,Bain, G.,Hutchinson, J.H.,Evans, J.F. (deposition date: 2015-04-22, release date: 2015-10-14, Last modification date: 2020-07-29)
Primary citation	Stein, A.J.,Bain, G.,Prodanovich, P.,Santini, A.M.,Darlington, J.,Stelzer, N.M.,Sidhu, R.S.,Schaub, J.,Goulet, L.,Lonergan, D.,Calderon, I.,Evans, J.F.,Hutchinson, J.H. Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88:982-992, 2015 Cited by PubMed: 26371182 DOI: 10.1124/mol.115.100404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation