4RCP

Crystal structure of Plk1 Polo-box domain in complex with PL-2

Summary for 4RCP

Entry DOI	10.2210/pdb4rcp/pdb
Related PRD ID	PRD_001254
Descriptor	Serine/threonine-protein kinase PLK1, PL-2, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	polo-box domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P53350
Total number of polymer chains	2
Total formula weight	27628.45
Authors	Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2014-09-16, release date: 2014-11-12, Last modification date: 2015-01-21)
Primary citation	Ahn, M.,Han, Y.H.,Park, J.E.,Kim, S.,Lee, W.C.,Lee, S.J.,Gunasekaran, P.,Cheong, C.,Shin, S.Y.,Kim, H.Y.,Ryu, E.K.,Murugan, R.N.,Kim, N.H.,Bang, J.K. A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58:294-304, 2015 Cited by PubMed: 25347203 DOI: 10.1021/jm501147g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation