4RCP
Crystal structure of Plk1 Polo-box domain in complex with PL-2
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 601 |
| Chain | Residue |
| A | GLN379 |
| A | ASP416 |
| A | TYR417 |
| A | SER418 |
| A | ASP419 |
| A | HOH779 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 602 |
| Chain | Residue |
| A | ASP457 |
| A | HOH728 |
| A | GLY393 |
| A | GLU455 |
| A | ARG456 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 603 |
| Chain | Residue |
| A | CYS372 |
| A | HIS373 |
| A | ASP376 |
| A | TYR421 |
| B | 56A2 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| Chain | Residue |
| A | GLN380 |
| A | TYR481 |
| A | TYR485 |
| A | PRO545 |
| A | LEU546 |
| A | HOH767 |
| B | 56A2 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 605 |
| Chain | Residue |
| A | GLU401 |
| A | ILE406 |
| A | PHE559 |
| A | ARG560 |
| A | THR561 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 606 |
| Chain | Residue |
| A | GLY393 |
| A | LEU394 |
| A | VAL395 |
| A | TYR453 |
| A | SER471 |
| A | LEU472 |
| A | HOH820 |
| A | HOH834 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 607 |
| Chain | Residue |
| A | LYS420 |
| A | TYR421 |
| A | PHE436 |
| A | ASN437 |
| A | ASP438 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 608 |
| Chain | Residue |
| A | TRP514 |
| A | PHE515 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 609 |
| Chain | Residue |
| A | PHE534 |
| A | GLN536 |
| A | ASP537 |
| A | ARG579 |
| A | HOH739 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 610 |
| Chain | Residue |
| A | LYS413 |
| A | GLU488 |
| A | HIS489 |
| A | LEU490 |
| A | HOH783 |
| site_id | BC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR CHAIN B OF PL-2 |
| Chain | Residue |
| A | ASP376 |
| A | GLN379 |
| A | SER383 |
| A | LYS413 |
| A | TRP414 |
| A | VAL415 |
| A | ASP416 |
| A | TYR421 |
| A | TYR481 |
| A | TYR485 |
| A | LEU490 |
| A | LEU491 |
| A | HIS538 |
| A | LYS540 |
| A | GLU568 |
| A | EDO603 |
| A | EDO604 |
| A | HOH702 |
| A | HOH729 |
| B | HOH201 |
| B | HOH202 |
| B | HOH203 |
| B | HOH204 |
| B | HOH205 |
| B | HOH206 |
| B | HOH207 |
| B | HOH208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
