1KR3
Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050.
Summary for 1KR3
Entry DOI | 10.2210/pdb1kr3/pdb |
Related | 1DD6 1ZNB |
Descriptor | beta-Lactamase, type II, ZINC ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | beta sandwich, protein-inhibitor complex, metallo, beta-lactamase, hydrolase |
Biological source | Bacteroides fragilis |
Cellular location | Periplasm : P25910 |
Total number of polymer chains | 2 |
Total formula weight | 51669.40 |
Authors | Payne, D.J.,Hueso-Rodrguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Cheever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Dez, E.,Prez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. (deposition date: 2002-01-08, release date: 2003-01-08, Last modification date: 2023-08-16) |
Primary citation | Payne, D.J.,Hueso-Rodrguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Cheever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Dez, E.,Prez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases ANTIMICROB.AGENTS CHEMOTHER., 46:1880-1886, 2002 Cited by PubMed: 12019104DOI: 10.1128/AAC.46.6.1880-1886.2002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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