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PDB: 42 件
1GG8
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BU of 1gg8 by Molmil
DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS
分子名称: ALPHA-D-GLUCOPYRANOSYL-2-CARBOXYLIC ACID AMIDE, INOSINIC ACID, PROTEIN (GLYCOGEN PHOSPHORYLASE), ...
著者Watson, K.A, Mitchell, E.P, Johnson, L.N, Son, J.C, Bichard, C.J, Orchard, M.G, Fleet, G.W, Oikonomakos, N.G, Leonidas, D.D, Kontou, M, Papageorgiou, A.C.
登録日2000-07-30
公開日2000-08-23
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.
Biochemistry, 33, 1994
5XOX
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BU of 5xox by Molmil
Crystal structure of tRNA(His) guanylyltranserase from Saccharomyces cerevisiae
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Lee, K, Lee, E.H, Son, J, Hwang, K.Y.
登録日2017-05-31
公開日2017-07-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of tRNA(His) guanylyltransferase from Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun., 490, 2017
5EY2
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BU of 5ey2 by Molmil
Crystal structure of CodY from Bacillus cereus
分子名称: GTP-sensing transcriptional pleiotropic repressor CodY
著者Han, A, Lee, W.C, Son, J, Kim, S.H, Hwang, K.Y.
登録日2015-11-24
公開日2016-09-14
最終更新日2020-02-19
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism
Nucleic Acids Res., 44, 2016
6KIE
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BU of 6kie by Molmil
Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form
分子名称: 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ...
著者Kim, S, Son, J, Kim, S, Hwang, K.Y.
登録日2019-07-18
公開日2021-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KID
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BU of 6kid by Molmil
Crystal structure of human leucyl-tRNA synthetase, ATP-bound form
分子名称: ADENOSINE-5'-TRIPHOSPHATE, LEUCINE, Leucine--tRNA ligase, ...
著者Kim, S, Son, J, Kim, S, Hwang, K.Y.
登録日2019-07-18
公開日2021-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KQY
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BU of 6kqy by Molmil
Crystal structure of human leucyl-tRNA synthetase, Leucine-bound form
分子名称: LEUCINE, Leucine--tRNA ligase, cytoplasmic, ...
著者Kim, S, Son, J, Kim, S, Hwang, K.Y.
登録日2019-08-20
公開日2021-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KR7
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BU of 6kr7 by Molmil
Crystal structure of methylated human leucyl-tRNA synthetase, Leu-AMS-bound form
分子名称: 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ...
著者Kim, S, Son, J, Kim, S, Hwang, K.Y.
登録日2019-08-21
公開日2021-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
7CHT
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BU of 7cht by Molmil
Crystal structure of TTK kinase domain in complex with compound 30
分子名称: 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK, MAGNESIUM ION
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Ko, E.H, Choi, H.G, Son, J.B, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CHM
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BU of 7chm by Molmil
Crystal structure of TTK kinase domain in complex with compound 8
分子名称: 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CHN
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BU of 7chn by Molmil
Crystal structure of TTK kinase domain in complex with compound 9
分子名称: 4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CLH
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BU of 7clh by Molmil
Crystal structure of TTK kinase domain in complex with compound 19
分子名称: 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-21
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CJA
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BU of 7cja by Molmil
Crystal structure of TTK kinase domain in complex with compound 28
分子名称: 4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-09
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CIL
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BU of 7cil by Molmil
Crystal structure of TTK kinase domain in complex with compound 7
分子名称: 4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-07
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7E3R
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BU of 7e3r by Molmil
Crystal structure of TrmL from Vibrio vulnificus
分子名称: tRNA (cytidine(34)-2'-O)-methyltransferase
著者Kim, J, Son, J.
登録日2021-02-09
公開日2022-02-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal structure of tRNA mehtyltransferase TrmL from Vibrio vulnificus
To be published
7E3Q
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BU of 7e3q by Molmil
Crystal structure of SAH bound TrmL from Vibrio vulnificus
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytidine(34)-2'-O)-methyltransferase
著者Kim, J, Son, J.
登録日2021-02-09
公開日2022-02-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of SAH bound TrmL from Vibrio vulnificus
To Be Published
7E3T
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BU of 7e3t by Molmil
Crystal structure of TrmL from Mycoplasma capricolum
分子名称: Putative tRNA (cytidine(34)-2'-O)-methyltransferase
著者Kim, J, Son, J.
登録日2021-02-09
公開日2022-02-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of TrmL from Mycoplasma capricolum
To Be Published
7E3S
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BU of 7e3s by Molmil
Crystal structure of TrmL from Shewanella oneidensis
分子名称: tRNA (cytidine(34)-2'-O)-methyltransferase
著者Kim, J, Son, J.
登録日2021-02-09
公開日2022-02-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of TrmL from Shewanella oneidensis
To be Published
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