5ML9

Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.

Summary for 5ML9

• Entry DOI: 10.2210/pdb5ml9/pdb
• Descriptor: Low affinity immunoglobulin gamma Fc region receptor III-A, Affimer F4 with specificity for Fc gamma receptor IIIa, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: fc gamma receptor iiia affimer competitive inhibitor fcgr3a, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34676.97

Authors

Robinson, J.I.,Tomlinson, D.C.,Baxter, E.W.,Owen, R.L.,Thomsen, M.,Win, S.J.,Nettleship, J.E.,Tiede, C.,Foster, R.J.,Waterhouse, M.P.,Harris, S.A.,Owens, R.J.,Fishwick, C.W.G.,Goldman, A.,McPherson, M.J.,Morgan, A.W. (deposition date: 2016-12-06, release date: 2017-12-13, Last modification date: 2020-07-29)

• Primary citation: Robinson, J.I.,Baxter, E.W.,Owen, R.L.,Thomsen, M.,Tomlinson, D.C.,Waterhouse, M.P.,Win, S.J.,Nettleship, J.E.,Tiede, C.,Foster, R.J.,Owens, R.J.,Fishwick, C.W.G.,Harris, S.A.,Goldman, A.,McPherson, M.J.,Morgan, A.W.; Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.; Proc. Natl. Acad. Sci. U.S.A., 115:E72-E81, 2018; PubMed: 29247053; DOI: 10.1073/pnas.1707856115

Experimental method

X-RAY DIFFRACTION (2.35 Å)