5ML9
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Low affinity immunoglobulin gamma Fc region receptor III-A | polymer | 175 | 20028.3 | 1 | UniProt (P08637) Pfam (PF13895) | Homo sapiens (Human) | CD16a antigen,Fc-gamma RIII-alpha,FcRIIIa,FcR-10,IgG Fc receptor III-2 |
| 2 | B (B) | Affimer F4 with specificity for Fc gamma receptor IIIa | polymer | 115 | 13236.9 | 1 | synthetic construct | ||
| 3 | C, D, E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | F, G, M (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | H, I, J, K (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | N, O (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A: 1 - 175 (UniProt: P08637)
| PDB | External Database | Details |
|---|---|---|
| Val 158 | Phe 176 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33265.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1411.7 | |
| All* | Total formula weight | 34677.0 |
