8W2L
| TRPM7 structure in complex with anticancer agent CCT128930 in closed state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium, ... | Authors: | Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2024-02-20 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Cell Rep, 43, 2024
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9B35
| Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344 | Descriptor: | GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2 | Authors: | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | Deposit date: | 2024-03-18 | Release date: | 2024-05-22 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Kainate receptor channel opening and gating mechanism. Nature, 630, 2024
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5WEN
| GluA2 bound to GSG1L in digitonin, state 2 | Descriptor: | Digitonin, Glutamate receptor 2,Germ cell-specific gene 1-like protein | Authors: | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | Deposit date: | 2017-07-10 | Release date: | 2017-08-02 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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6XSR
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5WO6
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6VE8
| Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Methionine | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Gangwar, S.P, Green, M.N, Yoder, J.B, Sobolevsky, A.I. | Deposit date: | 2019-12-30 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain. Structure, 29, 2021
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6VEA
| Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine | Descriptor: | BETA-MERCAPTOETHANOL, GLYCINE, Glutamate receptor 3.2, ... | Authors: | Gangwar, S.P, Green, M.N, Yoder, J.B, Sobolevsky, A.I. | Deposit date: | 2019-12-30 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain. Structure, 29, 2021
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7UGG
| Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2022-03-24 | Release date: | 2022-06-08 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
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6PW5
| Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Nanodiscs | Descriptor: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, TRP-like ion channel, ... | Authors: | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | Deposit date: | 2019-07-22 | Release date: | 2019-09-25 | Last modified: | 2019-12-04 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii. Nat Commun, 10, 2019
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6PW4
| Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent | Descriptor: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | Deposit date: | 2019-07-22 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii. Nat Commun, 10, 2019
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8GF8
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GF9
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and POPC:POPE:POPG lipids | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GFA
| Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | Descriptor: | (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8FOB
| Cryo-EM structure of human TRPV6 in the open state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | Authors: | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2022-12-30 | Release date: | 2023-05-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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8FOA
| Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2022-12-30 | Release date: | 2023-05-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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7D2K
| Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a | Descriptor: | 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | Authors: | Singh, A.K, Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2020-09-16 | Release date: | 2021-10-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.698 Å) | Cite: | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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6PVN
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6PVQ
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6PVL
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6PVM
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6PVO
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6BOA
| Cryo-EM structure of human TRPV6-R470E in amphipols | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | Deposit date: | 2017-11-18 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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6BO9
| Cryo-EM structure of human TRPV6 in amphipols | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | Deposit date: | 2017-11-18 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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6BO8
| Cryo-EM structure of human TRPV6 in nanodiscs | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | Deposit date: | 2017-11-18 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
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6PVP
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