1V54
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![BU of 1v54 by Molmil](/molmil-images/mine/1v54) | Bovine heart cytochrome c oxidase at the fully oxidized state | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Tsukihara, T, Shimokata, K, Katayama, Y, Shimada, H, Muramoto, K, Aoyama, H, Mochizuki, M, Shinzawa-Itoh, K, Yamashita, E, Yao, M, Ishimura, Y, Yoshikawa, S. | Deposit date: | 2003-11-21 | Release date: | 2003-12-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process. Proc.Natl.Acad.Sci.Usa, 100, 2003
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8YHR
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![BU of 8yhr by Molmil](/molmil-images/mine/8yhr) | DHODH in complex with furocoumavirin | Descriptor: | 4-methyl-8-[(S)-oxidanyl(phenyl)methyl]-9-phenyl-furo[2,3-h]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Hara, K, Okumura, H, Nakahara, M, Sato, M, Hashimoto, H, Osada, H, Watanabe, K. | Deposit date: | 2024-02-28 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin. Biochemistry, 63, 2024
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3AXG
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![BU of 3axg by Molmil](/molmil-images/mine/3axg) | Structure of 6-aminohexanoate-oligomer hydrolase | Descriptor: | Endotype 6-aminohexanoat-oligomer hydrolase, SODIUM ION | Authors: | Negoro, S, Shibata, N, Tanaka, Y, Yasuhira, K, Shibata, H, Hashimoto, H, Lee, Y.H, Ohshima, S, Santa, R, Mochiji, K, Goto, Y, Ikegami, T, Nagai, K, Kato, D, Takeo, M, Higuchi, Y. | Deposit date: | 2011-04-04 | Release date: | 2011-12-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis J.Biol.Chem., 287, 2012
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2RVQ
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![BU of 2rvq by Molmil](/molmil-images/mine/2rvq) | Solution structure of the isolated histone H2A-H2B heterodimer | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-J | Authors: | Moriwaki, Y, Yamane, T, Ohtomo, H, Ikeguchi, M, Kurita, J, Sato, M, Nagadoi, A, Shimojo, H, Nishimura, Y. | Deposit date: | 2016-03-28 | Release date: | 2016-05-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the isolated histone H2A-H2B heterodimer Sci Rep, 6, 2016
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1FH1
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![BU of 1fh1 by Molmil](/molmil-images/mine/1fh1) | |
6IGX
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![BU of 6igx by Molmil](/molmil-images/mine/6igx) | Crystal structure of human CAP-G in complex with CAP-H | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Condensin complex subunit 2, Condensin complex subunit 3 | Authors: | Hara, K, Migita, T, Shimizu, K, Hashimoto, H. | Deposit date: | 2018-09-26 | Release date: | 2019-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.995 Å) | Cite: | Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. Embo Rep., 20, 2019
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1WDA
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![BU of 1wda by Molmil](/molmil-images/mine/1wda) | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide | Descriptor: | CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ... | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | Deposit date: | 2004-05-12 | Release date: | 2004-07-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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1WD9
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![BU of 1wd9 by Molmil](/molmil-images/mine/1wd9) | Calcium bound form of human peptidylarginine deiminase type4 (PAD4) | Descriptor: | CALCIUM ION, Protein-arginine deiminase type IV, SULFATE ION | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | Deposit date: | 2004-05-12 | Release date: | 2004-07-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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3I4D
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![BU of 3i4d by Molmil](/molmil-images/mine/3i4d) | Photosynthetic reaction center from rhodobacter sphaeroides 2.4.1 | Descriptor: | (2R,3S)-heptane-1,2,3-triol, 1,4-DIETHYLENE DIOXIDE, BACTERIOCHLOROPHYLL A, ... | Authors: | Fujii, R, Adachi, S, Roszak, A.W, Gardiner, A.T, Cogdell, R.J, Isaacs, N.W, Koshihara, S, Hashimoto, H. | Deposit date: | 2009-07-01 | Release date: | 2010-12-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of the carotenoid bound to the reaction centre from Rhodobacter sphaeroides 2.4.1 revealed by time-resolved X-ray crystallography To be Published
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8FJM
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![BU of 8fjm by Molmil](/molmil-images/mine/8fjm) | Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - P212121 space group | Descriptor: | ACETATE ION, CALCIUM ION, Histone-lysine N-methyltransferase, ... | Authors: | Frisbie, V.S, Hashimoto, H, Debler, E.W. | Deposit date: | 2022-12-20 | Release date: | 2024-02-07 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids. Nat Commun, 15, 2024
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8GS2
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![BU of 8gs2 by Molmil](/molmil-images/mine/8gs2) | Structure of the Cas7-11-Csx29-guide RNA-target RNA (non-matching PFS) complex | Descriptor: | ADENOSINE MONOPHOSPHATE, CHAT domain-containing protein, CRISPR-associated RAMP family protein, ... | Authors: | Kato, K, Okazaki, S, Ishikawa, J, Isayama, Y, Nishizawa, T, Nishimasu, H. | Deposit date: | 2022-09-04 | Release date: | 2022-11-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease. Science, 378, 2022
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3B0T
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![BU of 3b0t by Molmil](/molmil-images/mine/3b0t) | Human VDR ligand binding domain in complex with maxacalcitol | Descriptor: | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor | Authors: | Hishiki, A, Hashimoto, H, Sato, M, Shimizu, T. | Deposit date: | 2011-06-14 | Release date: | 2011-08-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Human VDR ligand binding domain in complex with maxacalcitol To be Published
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8GNN
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![BU of 8gnn by Molmil](/molmil-images/mine/8gnn) | Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex | Descriptor: | Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Cell cycle checkpoint protein RAD17, ... | Authors: | Hara, K, Nagata, K, Iida, N, Hashimoto, H. | Deposit date: | 2022-08-24 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.119 Å) | Cite: | The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. J.Biol.Chem., 299, 2023
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3B0R
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![BU of 3b0r by Molmil](/molmil-images/mine/3b0r) | |
8X5V
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![BU of 8x5v by Molmil](/molmil-images/mine/8x5v) | BlCas9-sgRNA-target DNA complex | Descriptor: | 1,2-ETHANEDIOL, BlCas9, CHLORIDE ION, ... | Authors: | Nakane, T, Nakagawa, R, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2023-11-19 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and engineering of Brevibacillus laterosporus Cas9. Commun Biol, 7, 2024
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6LMT
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![BU of 6lmt by Molmil](/molmil-images/mine/6lmt) | Cryo-EM structure of the killifish CALHM1 | Descriptor: | CHOLESTEROL HEMISUCCINATE, Calcium homeostasis modulator 1 | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-12-26 | Release date: | 2020-07-29 | Last modified: | 2020-09-09 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv, 6, 2020
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6MR4
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![BU of 6mr4 by Molmil](/molmil-images/mine/6mr4) | Crystal structure of the Sth1 bromodomain from S.cerevisiae | Descriptor: | Nuclear protein STH1/NPS1 | Authors: | Seo, H.S, Hashimoto, H, Krolak, A, Debler, E.W, Blus, B.J. | Deposit date: | 2018-10-11 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Substrate Affinity and Specificity of the ScSth1p Bromodomain Are Fine-Tuned for Versatile Histone Recognition. Structure, 27, 2019
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5EGH
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![BU of 5egh by Molmil](/molmil-images/mine/5egh) | Structure of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase in complex with phosphocholine | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Morita, J, Kano, K, Kato, K, Takita, H, Ishitani, R, Nishimasu, H, Nureki, O, Aoki, J. | Deposit date: | 2015-10-27 | Release date: | 2016-03-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase Sci Rep, 6, 2016
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8ZH8
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![BU of 8zh8 by Molmil](/molmil-images/mine/8zh8) | Human GPR103 -Gq complex bound to QRFP26 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O. | Deposit date: | 2024-05-10 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103. Nat Commun, 15, 2024
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5EGE
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![BU of 5ege by Molmil](/molmil-images/mine/5ege) | Structure of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Morita, J, Kano, K, Kato, K, Takita, H, Ishitani, R, Nishimasu, H, Nureki, O, Aoki, J. | Deposit date: | 2015-10-27 | Release date: | 2016-03-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase Sci Rep, 6, 2016
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8W7D
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![BU of 8w7d by Molmil](/molmil-images/mine/8w7d) | Crystal structure of EcPPAT-FR901483 complex | Descriptor: | Amidophosphoribosyltransferase, [(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate | Authors: | Hara, K, Hashimoto, H, Nakahara, M, Sato, M, Watanabe, K. | Deposit date: | 2023-08-30 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor. J.Am.Chem.Soc., 145, 2023
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4PDT
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![BU of 4pdt by Molmil](/molmil-images/mine/4pdt) | Japanese Marasmius oreades lectin | Descriptor: | Mannose recognizing lectin, SULFATE ION | Authors: | Noma, Y, Shimokawa, M, Maeganeku, C, Motoshima, H, Watanabe, K, Minami, Y, Yagi, F. | Deposit date: | 2014-04-22 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The structure of Japanese Marasmius oreades lectin at 1.40 Angstroms resolution. To Be Published
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1UHN
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![BU of 1uhn by Molmil](/molmil-images/mine/1uhn) | The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana | Descriptor: | CALCIUM ION, calcineurin B-like protein 2 | Authors: | Nagae, M, Nozawa, A, Koizumi, N, Sano, H, Hashimoto, H, Sato, M, Shimizu, T. | Deposit date: | 2003-07-07 | Release date: | 2003-11-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana J.Biol.Chem., 278, 2003
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7C7L
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![BU of 7c7l by Molmil](/molmil-images/mine/7c7l) | Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex | Descriptor: | CRISPR-associated protein Cas14a.1, DNA (40-mer), ZINC ION, ... | Authors: | Takeda, N.S, Nakagawa, R, Okazaki, S, Hirano, H, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2020-05-26 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the miniature type V-F CRISPR-Cas effector enzyme. Mol.Cell, 81, 2021
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2P9Y
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![BU of 2p9y by Molmil](/molmil-images/mine/2p9y) | Crystal structure of TTHB049 from Thermus thermophilus HB8 | Descriptor: | Alpha-ribazole-5'-phosphate phosphatase, GLYCEROL, SODIUM ION | Authors: | Sugahara, M, Matsuura, Y, Kageyama, Y, Shimada, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-26 | Release date: | 2007-10-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of TTHB049 from Thermus thermophilus HB8 To be Published
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