5JHL
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![BU of 5jhl by Molmil](/molmil-images/mine/5jhl) | Crystal structure of zika virus envelope protein in complex with a flavivirus broadly-protective antibody | Descriptor: | Antibody Heavy chain, antibody Light chain, envelope protein | Authors: | Dai, L, Shi, Y, Qi, J, Gao, G.F. | Deposit date: | 2016-04-21 | Release date: | 2016-05-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. Cell Host Microbe, 19, 2016
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5JHM
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5JD0
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![BU of 5jd0 by Molmil](/molmil-images/mine/5jd0) | crystal structure of ARAP3 RhoGAP domain | Descriptor: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | Authors: | Bao, H, Li, F, Wu, J, Shi, Y. | Deposit date: | 2016-04-15 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem., 291, 2016
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6J6G
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![BU of 6j6g by Molmil](/molmil-images/mine/6j6g) | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6IYC
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![BU of 6iyc by Molmil](/molmil-images/mine/6iyc) | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | Deposit date: | 2018-12-14 | Release date: | 2019-01-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
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6J6H
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![BU of 6j6h by Molmil](/molmil-images/mine/6j6h) | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J6N
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![BU of 6j6n by Molmil](/molmil-images/mine/6j6n) | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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7T0C
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![BU of 7t0c by Molmil](/molmil-images/mine/7t0c) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0D
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![BU of 7t0d by Molmil](/molmil-images/mine/7t0d) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.906 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0B
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![BU of 7t0b by Molmil](/molmil-images/mine/7t0b) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.026 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0E
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![BU of 7t0e by Molmil](/molmil-images/mine/7t0e) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one, 1,2-ETHANEDIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.223 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0A
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![BU of 7t0a by Molmil](/molmil-images/mine/7t0a) | Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T09
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![BU of 7t09 by Molmil](/molmil-images/mine/7t09) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.984 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T08
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![BU of 7t08 by Molmil](/molmil-images/mine/7t08) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2021-11-29 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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8E9E
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![BU of 8e9e by Molmil](/molmil-images/mine/8e9e) | Rat protein farnesyltransferase in complex with FPP and inhibitor 2f | Descriptor: | (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Wang, Y, Shi, Y, Beese, L.S. | Deposit date: | 2022-08-26 | Release date: | 2022-10-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.844 Å) | Cite: | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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8BW1
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![BU of 8bw1 by Molmil](/molmil-images/mine/8bw1) | Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL) | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Bozhueyuek, K.A.J, Praeve, L, Kegler, C, Kaiser, S, Shi, Y, Kuttenlochner, W, Schenk, L, Groll, M, Hochberg, G.K.A, Bode, H.B. | Deposit date: | 2022-12-06 | Release date: | 2023-12-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Evolution-inspired engineering of nonribosomal peptide synthetases. Science, 383, 2024
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4RHW
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![BU of 4rhw by Molmil](/molmil-images/mine/4rhw) | Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | Descriptor: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | Authors: | Hu, Q, Wu, D, Yan, C, Shi, Y. | Deposit date: | 2014-10-03 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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6IEX
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![BU of 6iex by Molmil](/molmil-images/mine/6iex) | Crystal structure of HLA-B*4001 in complex with SARS-CoV derived peptide N216-225 GETALALLLL | Descriptor: | Beta-2-microglobulin, GLY-GLU-THR-ALA-LEU-ALA-LEU-LEU-LEU-LEU, MHC class I antigen | Authors: | Ji, W, Niu, L, Peng, W, Zhang, Y, Shi, Y, Qi, J, Gao, G.F, Liu, W.J. | Deposit date: | 2018-09-17 | Release date: | 2019-09-18 | Last modified: | 2021-03-31 | Method: | X-RAY DIFFRACTION (2.314 Å) | Cite: | Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner. Mol.Immunol., 112, 2019
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3GYO
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![BU of 3gyo by Molmil](/molmil-images/mine/3gyo) | Se-Met Rtt106p | Descriptor: | Histone chaperone RTT106 | Authors: | Liu, Y, Huang, H, Shi, Y, Teng, M. | Deposit date: | 2009-04-04 | Release date: | 2009-12-08 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
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3GYP
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![BU of 3gyp by Molmil](/molmil-images/mine/3gyp) | Rtt106p | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Histone chaperone RTT106 | Authors: | Liu, Y, Huang, H, Shi, Y, Teng, M. | Deposit date: | 2009-04-04 | Release date: | 2009-12-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.406 Å) | Cite: | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
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3JBM
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![BU of 3jbm by Molmil](/molmil-images/mine/3jbm) | Electron cryo-microscopy of a virus-like particle of orange-spotted grouper nervous necrosis virus | Descriptor: | virus-like particle of orange-spotted grouper nervous necrosis virus | Authors: | Xie, J, Li, K, Gao, Y, Huang, R, Lai, Y, Shi, Y, Yang, S, Zhu, G, Zhang, Q, He, J. | Deposit date: | 2015-09-06 | Release date: | 2016-10-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle Vet. Res., 47, 2016
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3J3T
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![BU of 3j3t by Molmil](/molmil-images/mine/3j3t) | Structural dynamics of the MecA-ClpC complex revealed by cryo-EM | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | Authors: | Liu, J, Mei, Z, Li, N, Qi, Y, Xu, Y, Shi, Y, Wang, F, Lei, J, Gao, N. | Deposit date: | 2013-04-18 | Release date: | 2013-05-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine. J.Biol.Chem., 288, 2013
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3J3R
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![BU of 3j3r by Molmil](/molmil-images/mine/3j3r) | Structural dynamics of the MecA-ClpC complex revealed by cryo-EM | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | Authors: | Liu, J, Mei, Z, Li, N, Qi, Y, Xu, Y, Shi, Y, Wang, F, Lei, J, Gao, N. | Deposit date: | 2013-04-18 | Release date: | 2013-05-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine J.Biol.Chem., 288, 2013
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4QY0
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![BU of 4qy0 by Molmil](/molmil-images/mine/4qy0) | Structure of H10 from human-infecting H10N8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin | Authors: | Wang, M, Zhang, W, Qi, J, Wang, F, Zhou, J, Bi, Y, Wu, Y, Sun, H, Liu, J, Huang, C, Li, X, Yan, J, Shu, Y, Shi, Y, Gao, G.F. | Deposit date: | 2014-07-23 | Release date: | 2015-01-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus Nat Commun, 6, 2015
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6DRD
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![BU of 6drd by Molmil](/molmil-images/mine/6drd) | RNA Pol II(G) | Descriptor: | DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | Yu, X, Jishage, M, Shi, Y, Ganesan, S, Sali, A, Chait, B.T, Asturias, F, Roeder, R.G. | Deposit date: | 2018-06-11 | Release date: | 2019-06-12 | Last modified: | 2019-12-04 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Nat. Struct. Mol. Biol., 25, 2018
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