7EXS
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![BU of 7exs by Molmil](/molmil-images/mine/7exs) | Thermomicrobium roseum sarcosine oxidase mutant - S320R | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Xin, Y, Shen, C, Tang, M.W, Shi, Y, Guo, Z.T, Gu, Z.H, Shao, J, Zhang, L. | Deposit date: | 2021-05-28 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Recreating the natural evolutionary trend in key microdomains provides an effective strategy for engineering of a thermomicrobial N-demethylase. J.Biol.Chem., 298, 2022
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7BCS
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![BU of 7bcs by Molmil](/molmil-images/mine/7bcs) | ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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2HV6
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2HV7
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7D7E
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![BU of 7d7e by Molmil](/molmil-images/mine/7d7e) | Structure of PKD1L3-CTD/PKD2L1 in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | Authors: | Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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1K88
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![BU of 1k88 by Molmil](/molmil-images/mine/1k88) | Crystal structure of procaspase-7 | Descriptor: | procaspase-7 | Authors: | Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. | Deposit date: | 2001-10-23 | Release date: | 2001-11-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
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7ELB
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![BU of 7elb by Molmil](/molmil-images/mine/7elb) | Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Peng, R, Xu, X, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELC
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![BU of 7elc by Molmil](/molmil-images/mine/7elc) | Structure of monomeric complex of MACV L bound to Z and 3'-vRNA | Descriptor: | 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELA
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![BU of 7ela by Molmil](/molmil-images/mine/7ela) | Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) | Descriptor: | 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7EL9
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![BU of 7el9 by Molmil](/molmil-images/mine/7el9) | Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex) | Descriptor: | MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ... | Authors: | Peng, R, Xu, X, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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1K86
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![BU of 1k86 by Molmil](/molmil-images/mine/1k86) | Crystal structure of caspase-7 | Descriptor: | caspase-7 | Authors: | Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. | Deposit date: | 2001-10-23 | Release date: | 2001-11-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
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2I8N
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7CKM
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![BU of 7ckm by Molmil](/molmil-images/mine/7ckm) | Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2020-07-17 | Release date: | 2021-05-05 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7CKL
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![BU of 7ckl by Molmil](/molmil-images/mine/7ckl) | Structure of Lassa virus polymerase bound to Z matrix protein | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2020-07-17 | Release date: | 2021-05-05 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7EVO
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![BU of 7evo by Molmil](/molmil-images/mine/7evo) | The cryo-EM structure of the human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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2JWE
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![BU of 2jwe by Molmil](/molmil-images/mine/2jwe) | Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping | Descriptor: | Tight junction protein ZO-1 | Authors: | Ji, P, Wu, J.W, Zhang, J.H, Yang, Y.S, Wu, J.H, Shi, Y.Y. | Deposit date: | 2007-10-10 | Release date: | 2007-10-30 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the second PDZ domain of Zonula Occludens 1 Proteins, 79, 2011
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1F0K
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![BU of 1f0k by Molmil](/molmil-images/mine/1f0k) | THE 1.9 ANGSTROM CRYSTAL STRUCTURE OF E. COLI MURG | Descriptor: | SULFATE ION, UDP-N-ACETYLGLUCOSAMINE-N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE | Authors: | Ha, S, Walker, D, Shi, Y, Walker, S. | Deposit date: | 2000-05-16 | Release date: | 2000-07-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis. Protein Sci., 9, 2000
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1G73
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![BU of 1g73 by Molmil](/molmil-images/mine/1g73) | CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN | Descriptor: | INHIBITORS OF APOPTOSIS-LIKE PROTEIN ILP, SECOND MITOCHONDRIA-DERIVED ACTIVATOR OF CASPASES, ZINC ION | Authors: | Wu, G, Chai, J, Suber, T.L, Wu, J.-W, Shi, Y. | Deposit date: | 2000-11-08 | Release date: | 2001-01-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of IAP recognition by Smac/DIABLO. Nature, 408, 2000
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7CTT
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![BU of 7ctt by Molmil](/molmil-images/mine/7ctt) | Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Peng, Q, Peng, R, Shi, Y. | Deposit date: | 2020-08-20 | Release date: | 2020-09-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021
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7XQ8
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![BU of 7xq8 by Molmil](/molmil-images/mine/7xq8) | Structure of human B-cell antigen receptor of the IgM isotype | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | Deposit date: | 2022-05-07 | Release date: | 2022-08-17 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of the human IgM B cell receptor. Science, 377, 2022
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7EVN
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![BU of 7evn by Molmil](/molmil-images/mine/7evn) | The cryo-EM structure of the DDX42-SF3b complex | Descriptor: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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1HW5
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![BU of 1hw5 by Molmil](/molmil-images/mine/1hw5) | THE CAP/CRP VARIANT T127L/S128A | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR | Authors: | Chu, S.Y, Tordova, M, Gilliland, G.L, Gorshkova, I, Shi, Y. | Deposit date: | 2001-01-09 | Release date: | 2001-01-17 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The structure of the T127L/S128A mutant of cAMP receptor protein facilitates promoter site binding J.Biol.Chem., 276, 2001
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1K99
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2JXW
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7DVQ
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![BU of 7dvq by Molmil](/molmil-images/mine/7dvq) | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | Deposit date: | 2021-01-14 | Release date: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of the activated human minor spliceosome. Science, 371, 2021
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