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PDB: 1971 results
8II0
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BU of 8ii0 by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine
Descriptor: 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
Deposit date:2023-02-24
Release date:2024-02-28
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
8IHZ
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BU of 8ihz by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine
Descriptor: 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
Deposit date:2023-02-24
Release date:2024-02-28
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
6IOT
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BU of 6iot by Molmil
The ligand binding domain of Mlp24 with arginine
Descriptor: ARGININE, CALCIUM ION, Methyl-accepting chemotaxis protein
Authors:Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K.
Deposit date:2018-10-31
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae.
J. Bacteriol., 201, 2019
6IOR
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BU of 6ior by Molmil
The ligand binding domain of Mlp24 with asparagine
Descriptor: ASPARAGINE, CALCIUM ION, Methyl-accepting chemotaxis protein
Authors:Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K.
Deposit date:2018-10-31
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae.
J. Bacteriol., 201, 2019
2YGS
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BU of 2ygs by Molmil
CARD DOMAIN FROM APAF-1
Descriptor: APOPTOTIC PROTEASE ACTIVATING FACTOR 1
Authors:Shi, Y.
Deposit date:1999-05-08
Release date:2000-04-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature, 399, 1999
6IOS
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BU of 6ios by Molmil
The ligand binding domain of Mlp24 with proline
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ...
Authors:Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K.
Deposit date:2018-10-31
Release date:2019-03-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae.
J. Bacteriol., 201, 2019
4XD7
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BU of 4xd7 by Molmil
Structure of thermophilic F1-ATPase inhibited by epsilon subunit
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP synthase epsilon chain, ATP synthase gamma chain, ...
Authors:SHIRAKIHARA, Y, SHIRATORI, A, TANIKAWA, H, NAKASAKO, M, YOSHIDA, M, SUZUKI, T.
Deposit date:2014-12-19
Release date:2015-08-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of a thermophilic F1 -ATPase inhibited by an epsilon-subunit: deeper insight into the epsilon-inhibition mechanism.
Febs J., 282, 2015
7R8F
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BU of 7r8f by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute
Descriptor: Argonaute
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-06-26
Release date:2022-07-06
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8K
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BU of 7r8k by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute (SeMet labeled protein)
Descriptor: Argonaute
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-06-26
Release date:2022-07-06
Last modified:2022-12-28
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8G
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BU of 7r8g by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA
Descriptor: Argonaute, DNA (5'-D(*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-06-26
Release date:2022-07-06
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8H
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BU of 7r8h by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' p guide DNA
Descriptor: Argonaute, DNA (5'-D(*TP*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-06-26
Release date:2022-07-06
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8I
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BU of 7r8i by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA in the presence of Mg2+
Descriptor: Argonaute, DNA (5'-D(*TP*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A), MAGNESIUM ION
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-06-26
Release date:2022-11-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA in the presence of Mg2+
To be published
7A1O
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BU of 7a1o by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-ethyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: 4-ethyl-2-oxoglutarate, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1Q
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BU of 7a1q by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1P
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BU of 7a1p by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-propyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: (4~{S})-2-oxidanylidene-4-propyl-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1M
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BU of 7a1m by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-propyl-2-oxoglutarate
Descriptor: 3-propyl-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1N
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BU of 7a1n by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1L
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BU of 7a1l by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1J
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BU of 7a1j by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-(3-phenylpropyl)-2-oxoglutarate
Descriptor: 3-(3-phenylpropyl)-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1S
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BU of 7a1s by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1K
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BU of 7a1k by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate
Descriptor: 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
6WOX
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BU of 6wox by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 2'dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2020-04-26
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
6WOY
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BU of 6woy by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP
Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2020-04-26
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
5AVE
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BU of 5ave by Molmil
The ligand binding domain of Mlp37 with serine
Descriptor: Methyl-accepting chemotaxis (MCP) signaling domain protein, SERINE
Authors:Takahashi, Y, Sumita, K, Uchida, Y, Nishiyama, S, Kawagishi, I, Imada, K.
Deposit date:2015-06-15
Release date:2016-03-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants
Sci Rep, 6, 2016
5AVF
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BU of 5avf by Molmil
The ligand binding domain of Mlp37 with taurine
Descriptor: 2-AMINOETHANESULFONIC ACID, Methyl-accepting chemotaxis (MCP) signaling domain protein
Authors:Takahashi, Y, Sumita, K, Uchida, Y, Nishiyama, S, Kawagishi, I, Imada, K.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants
Sci Rep, 6, 2016

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