7NP6
 
 | | ROR(gamma)t ligand binding domain in complex with allosteric ligand FM257 | | 分子名称: | 4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrazol-4-yl)-1,2-oxazol-4-yl]methoxy]benzoic acid, Nuclear receptor ROR-gamma | | 著者 | Oerlemans, G.J.M, Somsen, B.A, de Vries, R.M.J.M, Meijer, F.A, Brunsveld, L. | | 登録日 | 2021-02-26 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor gamma t.
J.Med.Chem., 64, 2021
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6GRQ
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5NNJ
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5LFU
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7O74
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7BAM
 | | human Teneurin4 WT C2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Meijer, D.H, Janssen, B.J.C. | | 登録日 | 2020-12-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.
Embo J., 41, 2022
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5JTF
 | | Crystal structure of ArsN N-acetyltransferase from Pseudomonas putida KT2440 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Putative Phosphinothricin N-acetyltransferase | | 著者 | Venkadesh, S, Dheeman, D.S, Kandavelu, P, Rosen, B.P. | | 登録日 | 2016-05-09 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | | 主引用文献 | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.
Commun Biol, 2, 2019
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7BAN
 | | human Teneurin4 Mut C2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Meijer, D.H, Janssen, B.J.C. | | 登録日 | 2020-12-16 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.
Embo J., 41, 2022
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8JFZ
 | | Cryo-EM structure of Na+,K+-ATPase in the E1.Mg2+ state. | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | | 登録日 | 2023-05-19 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
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8JBM
 | | Crystal structure of Na+,K+-ATPase in the E1.Mn2+ state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | | 登録日 | 2023-05-09 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
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8JBL
 | | Crystal structure of Na+,K+-ATPase in the E1.Mg2+ state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | | 登録日 | 2023-05-09 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
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6GRS
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7ABV
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6R4N
 | | Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, ... | | 著者 | Winkler, M.B.L, Kidmose, R.T, Pedersen, B.P. | | 登録日 | 2019-03-22 | | 公開日 | 2019-09-25 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
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6R4M
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7ANY
 | | Structure of the Laspartomycin C Friulimicin-like mutant in complex with Geranyl phosphate | | 分子名称: | CADMIUM ION, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Zeronian, M.R, Pearce, N.M, Lutz, M, Wood, T.M, Martin, N.I, Janssen, B.J.C. | | 登録日 | 2020-10-13 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.135 Å) | | 主引用文献 | Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures
Chem Sci, 13, 2022
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6R4L
 | | Crystal structure of S. cerevisia Niemann-Pick type C protein NCR1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, NPC intracellular cholesterol transporter 1-related protein 1, ... | | 著者 | Winkler, M.B.L, Kidmose, R.T, Pedersen, B.P. | | 登録日 | 2019-03-22 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
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5EQI
 | | Human GLUT1 in complex with Cytochalasin B | | 分子名称: | Cytochalasin B, Solute carrier family 2, facilitated glucose transporter member 1 | | 著者 | Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. | | 登録日 | 2015-11-12 | | 公開日 | 2016-04-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | | 主引用文献 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6FFY
 | | Structure of the mouse SorCS2-NGF complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-nerve growth factor, VPS10 domain-containing receptor SorCS2, ... | | 著者 | Leloup, N.O.L, Janssen, B.J.C. | | 登録日 | 2018-01-09 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Structural insights into SorCS2-Nerve Growth Factor complex formation.
Nat Commun, 9, 2018
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5NMR
 | | Monomeric mouse Sortilin extracellular domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Leloup, N.O.L, Loessl, P, Meijer, D.H.M, Heck, A.J.R, Thies-Weesie, D.M.E, Janssen, B.J.C. | | 登録日 | 2017-04-07 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.
Nat Commun, 8, 2017
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7BAO
 | | human Teneurin4 Mut C1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Meijer, D.H, Janssen, B.J.C. | | 登録日 | 2020-12-16 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.
Embo J., 41, 2022
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5AMO
 | | Structure of a mouse Olfactomedin-1 disulfide-linked dimer of the Olfactomedin domain and part of the coiled coil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Pronker, M.F, Bos, T.G.A.A, Sharp, T.H, Thies-Weesie, D.M, Janssen, B.J.C. | | 登録日 | 2015-03-11 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Olfactomedin-1 Has a V-Shaped Disulfide-Linked Tetrameric Structure.
J.Biol.Chem., 290, 2015
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5L74
 | | Plexin A2 extracellular segment domains 4-5 (PSI2-IPT2), resolution 1.36 Angstrom | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Plexin-A2, ... | | 著者 | Kong, Y, Janssen, B.J.C, Malinauskas, T, Vangoor, V.R, Coles, C.H, Kaufmann, R, Ni, T, Gilbert, R.J.C, Padilla-Parra, S, Pasterkamp, R.J, Jones, E.Y. | | 登録日 | 2016-06-01 | | 公開日 | 2017-03-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
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5L7N
 | | Plexin A1 extracellular fragment, domains 7-10 (IPT3-IPT6) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kong, Y, Janssen, B.J.C, Malinauskas, T, Vangoor, V.R, Coles, C.H, Kaufmann, R, Ni, T, Gilbert, R.J.C, Padilla-Parra, S, Pasterkamp, R.J, Jones, E.Y. | | 登録日 | 2016-06-03 | | 公開日 | 2017-03-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
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6QM3
 | | Crystal structure of a calcium- and sodium-bound mouse Olfactomedin-1 disulfide-linked dimer of the Olfactomedin domain and part of coiled coil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CACODYLATE ION, ... | | 著者 | Pronker, M.F, van den Hoek, H.G, Janssen, B.J.C. | | 登録日 | 2019-02-01 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and structural characterisation of olfactomedin-1 variants as tools for functional studies.
BMC Mol Cell Biol, 20, 2019
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