5NNJ

Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom

Summary for 5NNJ

Entry DOI	10.2210/pdb5nnj/pdb
Descriptor	Sortilin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	transport receptor, vps10 domain, transport protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	331033.48
Authors	Leloup, N.O.L.,Janssen, B.J.C. (deposition date: 2017-04-09, release date: 2017-11-29, Last modification date: 2024-01-17)
Primary citation	Leloup, N.,Lossl, P.,Meijer, D.H.,Brennich, M.,Heck, A.J.R.,Thies-Weesie, D.M.E.,Janssen, B.J.C. Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8:1708-1708, 2017 Cited by PubMed: 29167428 DOI: 10.1038/s41467-017-01485-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation