2GIF
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![BU of 2gif by Molmil](/molmil-images/mine/2gif) | Asymmetric structure of trimeric AcrB from Escherichia coli | Descriptor: | Acriflavine resistance protein B, CITRATE ANION | Authors: | Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M. | Deposit date: | 2006-03-28 | Release date: | 2006-09-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism. Science, 313, 2006
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2HRT
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![BU of 2hrt by Molmil](/molmil-images/mine/2hrt) | Asymmetric structure of trimeric AcrB from Escherichia coli | Descriptor: | Acriflavine resistance protein B, CITRATE ANION | Authors: | Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M. | Deposit date: | 2006-07-20 | Release date: | 2006-09-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism. Science, 313, 2006
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4J8Y
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![BU of 4j8y by Molmil](/molmil-images/mine/4j8y) | E3_5 DARPin D77S mutant | Descriptor: | DARPin_E3_5_D77S | Authors: | Seeger, M.A, Gruetter, M.G. | Deposit date: | 2013-02-15 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci., 22, 2013
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4J7W
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![BU of 4j7w by Molmil](/molmil-images/mine/4j7w) | E3_5 DARPin L86A mutant | Descriptor: | DARPin_E3_5_L86A | Authors: | Seeger, M.A, Gruetter, M.G. | Deposit date: | 2013-02-14 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci., 22, 2013
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9FZD
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![BU of 9fzd by Molmil](/molmil-images/mine/9fzd) | |
9FZC
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![BU of 9fzc by Molmil](/molmil-images/mine/9fzc) | |
6QV1
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![BU of 6qv1 by Molmil](/molmil-images/mine/6qv1) | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1 | Descriptor: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | Authors: | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | Deposit date: | 2019-03-01 | Release date: | 2019-05-29 | Last modified: | 2019-06-05 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QV2
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![BU of 6qv2 by Molmil](/molmil-images/mine/6qv2) | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 | Descriptor: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | Authors: | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | Deposit date: | 2019-03-01 | Release date: | 2019-05-29 | Last modified: | 2019-06-05 | Method: | X-RAY DIFFRACTION (4.23 Å) | Cite: | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QUZ
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![BU of 6quz by Molmil](/molmil-images/mine/6quz) | Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | Descriptor: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | Authors: | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | Deposit date: | 2019-03-01 | Release date: | 2019-05-29 | Last modified: | 2019-06-05 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QV0
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![BU of 6qv0 by Molmil](/molmil-images/mine/6qv0) | Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | Descriptor: | ABC transporter, ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | Deposit date: | 2019-03-01 | Release date: | 2019-05-29 | Last modified: | 2019-06-05 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6LZ2
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![BU of 6lz2 by Molmil](/molmil-images/mine/6lz2) | Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb44) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... | Authors: | Cai, H, Yao, H, Li, T, Hutter, C, Tang, Y, Li, Y, Seeger, M, Li, D. | Deposit date: | 2020-02-17 | Release date: | 2020-12-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification. Commun Biol, 3, 2020
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6ZBV
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![BU of 6zbv by Molmil](/molmil-images/mine/6zbv) | Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7 | Descriptor: | Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone | Authors: | Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M.A, Schneider, T.R, Dawson, R.J.P, Nissen, P. | Deposit date: | 2020-06-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural insights into the inhibition of glycine reuptake. Nature, 591, 2021
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7CZ0
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![BU of 7cz0 by Molmil](/molmil-images/mine/7cz0) | Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) | Descriptor: | ACETATE ION, CACODYLATE ION, CACODYLIC ACID, ... | Authors: | Cai, H, Yao, H, Li, T, Hutter, C, Tang, Y, Li, Y, Seeger, M, Li, D. | Deposit date: | 2020-09-06 | Release date: | 2021-09-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | An improved fluorescent protein tag and its nanobodies for membrane protein expression, stability assay, and purification To Be Published
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8PNL
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![BU of 8pnl by Molmil](/molmil-images/mine/8pnl) | Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody | Descriptor: | Nb_H2, Putative triacylglyceride transporter | Authors: | Remm, S, Schoeppe, J, Hutter, C.A.J, Gonda, I, Seeger, M.A. | Deposit date: | 2023-06-30 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410. Nat Commun, 14, 2023
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3QF4
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![BU of 3qf4 by Molmil](/molmil-images/mine/3qf4) | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation | Descriptor: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | Authors: | Hohl, M, Briand, C, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2011-01-21 | Release date: | 2012-03-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Nat.Struct.Mol.Biol., 19, 2012
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6TEJ
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![BU of 6tej by Molmil](/molmil-images/mine/6tej) | Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5 | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Drug ABC transporter ATP-binding protein, NICKEL (II) ION, ... | Authors: | Gonda, I, Arnold, F.M, Hutter, C.A.J, Weber, M.S, Seeger, M.A, Hurlimann, L.M. | Deposit date: | 2019-11-12 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature, 580, 2020
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6TEK
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![BU of 6tek by Molmil](/molmil-images/mine/6tek) | Structure of siderophore interaction domain of IrtAB | Descriptor: | Drug ABC transporter ATP-binding protein, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Arnold, F.M, Gonda, I, Hutter, C.A.J, Seeger, M.A, Hurlimann, L.M. | Deposit date: | 2019-11-12 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature, 580, 2020
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4DX5
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![BU of 4dx5 by Molmil](/molmil-images/mine/4dx5) | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, DARPIN, ... | Authors: | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | Deposit date: | 2012-02-27 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DX7
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![BU of 4dx7 by Molmil](/molmil-images/mine/4dx7) | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | Descriptor: | Acriflavine resistance protein B, DARPIN, DECANE, ... | Authors: | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | Deposit date: | 2012-02-27 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.253 Å) | Cite: | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DX6
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![BU of 4dx6 by Molmil](/molmil-images/mine/4dx6) | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | Descriptor: | Acriflavine resistance protein B, DARPIN, DODECYL-BETA-D-MALTOSIDE | Authors: | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | Deposit date: | 2012-02-27 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc.Natl.Acad.Sci.USA, 109, 2012
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7B73
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![BU of 7b73 by Molmil](/molmil-images/mine/7b73) | Insight into the molecular determinants of thermal stability in halohydrin dehalogenase HheD2. | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Short-chain dehydrogenase/reductase SDR | Authors: | Wessel, J, Petrillo, G, Estevez, M, Bosh, S, Seeger, M, Dijkman, W.P, Hidalgo, A, Uson, I, Osuna, S, Schallmey, A. | Deposit date: | 2020-12-09 | Release date: | 2021-04-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Insights into the molecular determinants of thermal stability in halohydrin dehalogenase HheD2. Febs J., 288, 2021
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5F5U
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![BU of 5f5u by Molmil](/molmil-images/mine/5f5u) | Crystal structure of the Snu23-Prp38-MFAP1(217-258) complex of Chaetomium thermophilum | Descriptor: | Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein | Authors: | Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C. | Deposit date: | 2015-12-04 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.748 Å) | Cite: | Scaffolding in the Spliceosome via Single alpha Helices. Structure, 24, 2016
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5F5V
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![BU of 5f5v by Molmil](/molmil-images/mine/5f5v) | Crystal structure of the Snu23-Prp38-MFAP1(217-296) complex of Chaetomium thermophilum | Descriptor: | Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein | Authors: | Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C. | Deposit date: | 2015-12-04 | Release date: | 2016-10-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Scaffolding in the Spliceosome via Single alpha Helices. Structure, 24, 2016
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5OH6
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![BU of 5oh6 by Molmil](/molmil-images/mine/5oh6) | Legionella pneumophila RidL N-terminal domain lacking beta hairpin | Descriptor: | Interaptin | Authors: | Baerlocher, K, Hutter, C.A.J, Swart, A.L, Steiner, B, Welin, A, Hohl, M, Letourneur, F, Seeger, M.A, Hilbi, H. | Deposit date: | 2017-07-14 | Release date: | 2017-11-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun, 8, 2017
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5OH5
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![BU of 5oh5 by Molmil](/molmil-images/mine/5oh5) | Legionella pneumophila RidL N-terminal retromer binding domain | Descriptor: | RidL | Authors: | Baerlocher, K, Hutter, C.A.J, Swart, A.L, Steiner, B, Welin, A, Hohl, M, Letourneur, F, Seeger, M.A, Hilbi, H. | Deposit date: | 2017-07-14 | Release date: | 2017-11-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun, 8, 2017
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