2HRT

Asymmetric structure of trimeric AcrB from Escherichia coli

Summary for 2HRT

Entry DOI	10.2210/pdb2hrt/pdb
Descriptor	Acriflavine resistance protein B, CITRATE ANION (2 entities in total)
Functional Keywords	acrb, multidrug efflux pump, rnd, antibiotic resistance, acra, tolc, membrane protein, proton-coupled exchanger, transport protein
Biological source	Escherichia coli K12
Cellular location	Cell inner membrane; Multi-pass membrane protein: P31224
Total number of polymer chains	6
Total formula weight	689174.13
Authors	Seeger, M.A.,Schiefner, A.,Eicher, T.,Verrey, F.,Diederichs, K.,Pos, K.M. (deposition date: 2006-07-20, release date: 2006-09-12, Last modification date: 2023-08-30)
Primary citation	Seeger, M.A.,Schiefner, A.,Eicher, T.,Verrey, F.,Diederichs, K.,Pos, K.M. Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism. Science, 313:1295-1298, 2006 Cited by PubMed: 16946072 DOI: 10.1126/science.1131542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation