Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HRT

Asymmetric structure of trimeric AcrB from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015567	molecular_function	alkane transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0015895	biological_process	alkane transport
C	0015908	biological_process	fatty acid transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0009410	biological_process	response to xenobiotic stimulus
D	0009636	biological_process	response to toxic substance
D	0015125	molecular_function	bile acid transmembrane transporter activity
D	0015562	molecular_function	efflux transmembrane transporter activity
D	0015567	molecular_function	alkane transmembrane transporter activity
D	0015721	biological_process	bile acid and bile salt transport
D	0015895	biological_process	alkane transport
D	0015908	biological_process	fatty acid transport
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0042802	molecular_function	identical protein binding
D	0042908	biological_process	xenobiotic transport
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0042930	biological_process	enterobactin transport
D	0042931	molecular_function	enterobactin transmembrane transporter activity
D	0046677	biological_process	response to antibiotic
D	0055085	biological_process	transmembrane transport
D	0098567	cellular_component	periplasmic side of plasma membrane
D	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
D	1990281	cellular_component	efflux pump complex
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0015125	molecular_function	bile acid transmembrane transporter activity
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0015567	molecular_function	alkane transmembrane transporter activity
E	0015721	biological_process	bile acid and bile salt transport
E	0015895	biological_process	alkane transport
E	0015908	biological_process	fatty acid transport
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0042802	molecular_function	identical protein binding
E	0042908	biological_process	xenobiotic transport
E	0042910	molecular_function	xenobiotic transmembrane transporter activity
E	0042930	biological_process	enterobactin transport
E	0042931	molecular_function	enterobactin transmembrane transporter activity
E	0046677	biological_process	response to antibiotic
E	0055085	biological_process	transmembrane transport
E	0098567	cellular_component	periplasmic side of plasma membrane
E	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
E	1990281	cellular_component	efflux pump complex
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0009410	biological_process	response to xenobiotic stimulus
F	0009636	biological_process	response to toxic substance
F	0015125	molecular_function	bile acid transmembrane transporter activity
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0015567	molecular_function	alkane transmembrane transporter activity
F	0015721	biological_process	bile acid and bile salt transport
F	0015895	biological_process	alkane transport
F	0015908	biological_process	fatty acid transport
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0042802	molecular_function	identical protein binding
F	0042908	biological_process	xenobiotic transport
F	0042910	molecular_function	xenobiotic transmembrane transporter activity
F	0042930	biological_process	enterobactin transport
F	0042931	molecular_function	enterobactin transmembrane transporter activity
F	0046677	biological_process	response to antibiotic
F	0055085	biological_process	transmembrane transport
F	0098567	cellular_component	periplasmic side of plasma membrane
F	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
F	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC B 1058

Chain	Residue
A	ILE763
B	LYS55
B	GLN58
B	ASP59
B	GLY691
B	HIS692
B	LEU816

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FLC A 1058

Chain	Residue
A	ASP59
A	HIS692
C	ILE763
A	LYS55
A	GLN58

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC E 1058

Chain	Residue
D	ILE763
E	LYS55
E	GLN58
E	ASP59
E	GLY691
E	HIS692
E	LEU816

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC D 1058

Chain	Residue
D	LYS55
D	GLN58
D	ASP59
D	GLY691
D	HIS692
F	ILE763

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3864
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	114
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	696
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	114
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	126
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=8"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	114
Details	Transmembrane: {"description":"Helical; Name=9"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=10"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	114
Details	Transmembrane: {"description":"Helical; Name=11"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	114
Details	Transmembrane: {"description":"Helical; Name=12"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)