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PDB: 26 results
1WAQ
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BU of 1waq by Molmil
Crystal structure of human Growth and Differentiation Factor 5 (GDF-5)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2004-10-27
Release date:2005-05-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
J.Mol.Biol., 349, 2005
3BMP
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BU of 3bmp by Molmil
HUMAN BONE MORPHOGENETIC PROTEIN-2 (BMP-2)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN (BONE MORPHOGENETIC PROTEIN 2 (BMP-2))
Authors:Scheufler, C, Sebald, W, Huelsmeyer, M.
Deposit date:1999-03-12
Release date:2000-03-12
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.
J.Mol.Biol., 287, 1999
1REU
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BU of 1reu by Molmil
Structure of the bone morphogenetic protein 2 mutant L51P
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, bone morphogenetic protein 2
Authors:Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D.
Deposit date:2003-11-07
Release date:2004-05-04
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
1ES7
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BU of 1es7 by Molmil
COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
Descriptor: BONE MORPHOGENETIC PROTEIN RECEPTOR IA, BONE MORPHOGENETIC PROTEIN-2
Authors:Kirsch, T, Sebald, W, Dreyer, M.K.
Deposit date:2000-04-07
Release date:2000-10-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the BMP-2-BRIA ectodomain complex.
Nat.Struct.Biol., 7, 2000
1REW
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BU of 1rew by Molmil
Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
Descriptor: bone morphogenetic protein 2, bone morphogenetic protein receptor type IA
Authors:Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D.
Deposit date:2003-11-07
Release date:2004-05-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.863 Å)
Cite:Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
1IAR
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BU of 1iar by Molmil
INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
Descriptor: PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN), PROTEIN (INTERLEUKIN-4)
Authors:Hage, T, Sebald, W, Reinemer, P.
Deposit date:1999-02-25
Release date:2000-03-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
2MBK
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BU of 2mbk by Molmil
The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed
Descriptor: Crossveinless 2
Authors:Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W.
Deposit date:2013-08-02
Release date:2013-10-16
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed.
Molecules, 18, 2013
3NH7
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BU of 3nh7 by Molmil
Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA
Descriptor: Antibody fragment Fab AbD1556, heavy chain, light chain, ...
Authors:Mueller, T.D, Harth, S, Sebald, W.
Deposit date:2010-06-14
Release date:2010-10-27
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5, 2010
3QT2
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Structure of a cytokine ligand-receptor complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Interleukin-5, Interleukin-5 receptor subunit alpha, ...
Authors:Mueller, T.D, Patino, E, Kotzsch, A, Saremba, S, Nickel, J, Schmitz, W, Sebald, W.
Deposit date:2011-02-22
Release date:2012-02-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha.
Structure, 19, 2011
8A4F
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BU of 8a4f by Molmil
Human Interleukin-4 mutant - C3T-IL4
Descriptor: Interleukin-4
Authors:Vaz, D.C, Rodrigues, J.R, Mueller, T.D, Sebald, W, Redfield, C, Brito, R.M.M.
Deposit date:2022-06-11
Release date:2023-10-18
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
8CH7
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BU of 8ch7 by Molmil
RDC-refined Interleukin-4 (wild type) pH 5.6
Descriptor: Interleukin-4
Authors:Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M.
Deposit date:2023-02-07
Release date:2023-10-18
Last modified:2024-11-13
Method:SOLUTION NMR
Cite:Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
8CGF
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BU of 8cgf by Molmil
Interleukin-4 (wild type) pH 2.4
Descriptor: Interleukin-4
Authors:Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M.
Deposit date:2023-02-04
Release date:2023-10-18
Last modified:2024-10-09
Method:SOLUTION NMR
Cite:Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
3BK3
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BU of 3bk3 by Molmil
Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2
Descriptor: Bone morphogenetic protein 2, Crossveinless 2
Authors:Mueller, T.D, Sebald, W, Zhang, J.-L.
Deposit date:2007-12-05
Release date:2008-05-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
Dev.Cell, 14, 2008
3QB4
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BU of 3qb4 by Molmil
Crystal structure of a TGF-beta ligand-receptor complex
Descriptor: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2011-01-12
Release date:2012-03-14
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:GDF-5 can act as a context-dependent BMP-2 antagonist.
Bmc Biol., 13, 2015
2H64
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BU of 2h64 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D, Sebald, W, Weber, D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
1CYL
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BU of 1cyl by Molmil
ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Sebald, W, Oschkinat, H.
Deposit date:1994-02-21
Release date:1994-09-30
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
2R53
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BU of 2r53 by Molmil
Crystal structure analysis of Bone Morphogenetic Protein-6 variant B2 (B2-BMP-6)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Bone morphogenetic protein 6
Authors:Mueller, T.D, Sebald, W.
Deposit date:2007-09-03
Release date:2008-01-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
Febs J., 275, 2007
2R52
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BU of 2r52 by Molmil
Crystal structure analysis of Bone Morphogenetic Protein-6 (BMP-6)
Descriptor: Bone morphogenetic protein 6, ISOPROPYL ALCOHOL
Authors:Mueller, T.D, Sebald, W, Saremba, S.
Deposit date:2007-09-03
Release date:2008-01-15
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
Febs J., 275, 2007
2CYK
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BU of 2cyk by Molmil
ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Sebald, W, Oschkinat, H.
Deposit date:1994-08-16
Release date:1994-12-20
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
2B8X
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BU of 2b8x by Molmil
Crystal structure of the interleukin-4 variant F82D
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Z
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BU of 2b8z by Molmil
Crystal structure of the interleukin-4 variant R85A
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2D48
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BU of 2d48 by Molmil
Crystal structure of the Interleukin-4 variant T13D
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-11
Release date:2006-05-30
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B90
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BU of 2b90 by Molmil
Crystal structure of the interleukin-4 variant T13DR85A
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8U
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Crystal structure of wildtype human Interleukin-4
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Y
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Crystal structure of the interleukin-4 variant T13DF82D
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006

 

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