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PDB: 24 件
8EBM
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BU of 8ebm by Molmil
Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic
分子名称: ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8EBN
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Structure of KLHDC2-EloB/C tetrameric assembly
分子名称: Elongin-B, Elongin-C, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8EBL
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BU of 8ebl by Molmil
Structure of KLHDC2 substrate binding domain bound to C-degron from EPHB2
分子名称: GLU-ASP-SER-HIS-LYS-GLU-SER-ASN-ASP-CYS-SER-CYS-GLY-GLY, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
3O6B
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BU of 3o6b by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) low resolution
分子名称: Cell division control protein 53, Defective in cullin neddylation protein 1
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-28
公開日2010-09-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O2U
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BU of 3o2u by Molmil
S. cerevisiae Ubc12
分子名称: GLYCEROL, NEDD8-conjugating enzyme UBC12
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O2P
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BU of 3o2p by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB)
分子名称: Cell division control protein 53, Defective in cullin neddylation protein 1, GLYCEROL
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.233 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
4P5O
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Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate intermediate trapped in action
分子名称: Cullin-1, DCN1-like protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者Scott, D.C, Schulman, B.A.
登録日2014-03-18
公開日2014-07-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.1071 Å)
主引用文献Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8.
Cell, 157, 2014
3TDI
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BU of 3tdi by Molmil
yeast Cul1WHB-Dcn1P acetylated Ubc12N complex
分子名称: Defective in cullin neddylation protein 1, NEDD8-conjugating enzyme UBC12
著者Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A.
登録日2011-08-11
公開日2011-10-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science, 334, 2011
3TDZ
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N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-stapled acetylated Ubc12N complex
分子名称: Cullin-1, DCN1-like protein 1, STAPLED PEPTIDE
著者Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A.
登録日2011-08-11
公開日2011-10-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science, 334, 2011
3TDU
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N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-acetylated Ubc12N complex
分子名称: Cullin-1, DCN1-like protein 1, NEDD8-conjugating enzyme Ubc12
著者Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A.
登録日2011-08-11
公開日2011-10-12
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science, 334, 2011
5V89
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Structure of DCN4 PONY domain bound to CUL1 WHB
分子名称: Cullin-1, DCN1-like protein 4
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-03-21
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V83
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BU of 5v83 by Molmil
Structure of DCN1 bound to NAcM-HIT
分子名称: Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-03-21
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V86
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BU of 5v86 by Molmil
Structure of DCN1 bound to NAcM-OPT
分子名称: Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-03-21
公開日2017-05-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.374 Å)
主引用文献Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V88
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Structure of DCN1 bound to NAcM-COV
分子名称: Lysozyme,DCN1-like protein 1, N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]phenyl}propanamide
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-03-21
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
7KWA
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BU of 7kwa by Molmil
Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(trifluoromethyl)benzamide
分子名称: Endolysin,DCN1-like protein 1, N-[(4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-(trifluoromethyl)benzamide
著者Kim, H.S, Hammill, J.T, Schulman, B.A, Guy, R.K, Scott, D.C.
登録日2020-11-30
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.572 Å)
主引用文献Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.
J.Med.Chem., 64, 2021
6P5W
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BU of 6p5w by Molmil
Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
分子名称: 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide, Lysozyme,DCN1-like protein 1 chimera
著者Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A.
登録日2019-05-31
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019
6P5V
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BU of 6p5v by Molmil
Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Lysozyme,DCN1-like protein 1 fusion, N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide
著者Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A.
登録日2019-05-31
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.398 Å)
主引用文献Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019
6BG5
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Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1
分子名称: Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-10-27
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6BG3
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Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1
分子名称: Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea
著者Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
登録日2017-10-27
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
4GBA
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BU of 4gba by Molmil
DCNL complex with N-terminally acetylated NEDD8 E2 peptide
分子名称: DCN1-like protein 3, NEDD8-conjugating enzyme UBE2F
著者Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A.
登録日2012-07-26
公開日2012-11-28
最終更新日2013-01-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes.
Structure, 21, 2013
4GAO
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BU of 4gao by Molmil
DCNL complex with N-terminally acetylated NEDD8 E2 peptide
分子名称: BROMIDE ION, DCN1-like protein 2, NEDD8-conjugating enzyme Ubc12
著者Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A.
登録日2012-07-25
公開日2012-11-28
最終更新日2013-01-30
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes.
Structure, 21, 2013
3RTR
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BU of 3rtr by Molmil
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
分子名称: Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
著者Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A.
登録日2011-05-03
公開日2011-07-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
3FN1
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BU of 3fn1 by Molmil
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
分子名称: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
著者Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A.
登録日2008-12-22
公開日2009-03-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
3DQV
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Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
分子名称: Cullin-5, NEDD8, Rbx1, ...
著者Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A.
登録日2008-07-09
公開日2008-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Cell(Cambridge,Mass.), 134, 2008

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