5V83

Structure of DCN1 bound to NAcM-HIT

Summary for 5V83

Entry DOI	10.2210/pdb5v83/pdb
Related	5V86 5V88 5V89
Descriptor	Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	e3 ligase, hydrolase, ligase
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	1
Total formula weight	44684.75
Authors	Guy, R.K.,Schulman, B.A.,Scott, D.C.,Hammill, J.T. (deposition date: 2017-03-21, release date: 2017-05-24, Last modification date: 2023-10-04)
Primary citation	Scott, D.C.,Hammill, J.T.,Min, J.,Rhee, D.Y.,Connelly, M.,Sviderskiy, V.O.,Bhasin, D.,Chen, Y.,Ong, S.S.,Chai, S.C.,Goktug, A.N.,Huang, G.,Monda, J.K.,Low, J.,Kim, H.S.,Paulo, J.A.,Cannon, J.R.,Shelat, A.A.,Chen, T.,Kelsall, I.R.,Alpi, A.F.,Pagala, V.,Wang, X.,Peng, J.,Singh, B.,Harper, J.W.,Schulman, B.A.,Guy, R.K. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13:850-857, 2017 Cited by PubMed: 28581483 DOI: 10.1038/nchembio.2386 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.002 Å)

Structure validation