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PDB: 173 件
5K1U
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BU of 5k1u by Molmil
Crystal structure of reduced Shewanella Yellow Enzyme 4 (SYE4) in complex with the hydride Meisenheimer complex of trinitrophenol
分子名称: FLAVIN MONONUCLEOTIDE, NAD(P)H:flavin oxidoreductase Sye4, PICRIC ACID
著者Elegheert, J, Brige, A, Savvides, S.N.
登録日2016-05-18
公開日2017-06-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.
FEBS Lett., 591, 2017
5NR7
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BU of 5nr7 by Molmil
Mtb TMK crystal structure in complex with compound 43
分子名称: 1-[1-[[4-(3-chloranylphenoxy)quinolin-2-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-22
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
J. Med. Chem., 61, 2018
8OWF
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BU of 8owf by Molmil
Clostridium perfringens chitinase CP4_3455 with chitosan
分子名称: 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Chitodextrinase, ...
著者Bloch, Y, Savvides, S.N.
登録日2023-04-27
公開日2023-07-12
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Clostridium perfringens chitinase CP4_3455 with chitosan
To Be Published
6GFF
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BU of 6gff by Molmil
Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ...
著者Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S.
登録日2018-04-30
公開日2018-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 362, 2018
2ES4
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BU of 2es4 by Molmil
Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
分子名称: CALCIUM ION, IODIDE ION, Lipase, ...
著者Pauwels, K, Wyns, L, Tommassen, J, Savvides, S.N, Van Gelder, P.
登録日2005-10-25
公開日2006-03-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of a membrane-based steric chaperone in complex with its lipase substrate.
Nat.Struct.Mol.Biol., 13, 2006
8OVR
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BU of 8ovr by Molmil
Clostridium perfringens chitinase CP56_3454 apo form
分子名称: Chitinase B, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), SODIUM ION, ...
著者Bloch, Y, Savvides, S.N.
登録日2023-04-26
公開日2023-07-12
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Clostridium perfringens chitinase CP56_3454 apo form
To Be Published
3DK8
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BU of 3dk8 by Molmil
Catalytic cycle of human glutathione reductase near 1 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLYCEROL, ...
著者Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A.
登録日2008-06-24
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Catalytic cycle of human glutathione reductase near 1 A resolution.
J.Mol.Biol., 382, 2008
1TWX
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BU of 1twx by Molmil
Crystal structure of the thrombin mutant D221A/D222K
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin, Prothrombin
著者Pineda, A.O, Zhang, E, Guinto, E.R, Savvides, S.N, Tulinsky, A, Di Cera, E.
登録日2004-07-01
公開日2005-04-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form
Biophys.Chem., 112, 2004
4AWT
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BU of 4awt by Molmil
Crystal structure of the reduced Shewanella Yellow Enzyme 1 (SYE1) M25L mutant
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
著者Elegheert, J, Brige, A, Savvides, S.N.
登録日2012-06-05
公開日2013-06-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Modulation of Isoalloxazine Ring Planarity Influences Fmn Electronic Properties in Old Yellow Enzymes
To be Published
4AWS
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BU of 4aws by Molmil
Crystal structure of the oxidized Shewanella Yellow Enzyme 1 (SYE1) M25L mutant
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
著者Elegheert, J, Brige, A, Savvides, S.N.
登録日2012-06-05
公開日2013-06-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Modulation of Isoalloxazine Ring Planarity Influences Fmn Electronic Properties in Old Yellow Enzymes
To be Published
4ADF
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BU of 4adf by Molmil
CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1
分子名称: MACROPHAGE COLONY-STIMULATING FACTOR 1, SECRETED PROTEIN BARF1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Elegheert, J, Bracke, N, Savvides, S.N.
登録日2011-12-23
公開日2012-08-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1.
Nat.Struct.Mol.Biol., 19, 2012
3DJJ
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BU of 3djj by Molmil
Catalytic cycle of human glutathione reductase near 1 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Glutathione reductase, ...
著者Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A.
登録日2008-06-23
公開日2008-08-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Catalytic cycle of human glutathione reductase near 1 A resolution.
J.Mol.Biol., 382, 2008
3DK4
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BU of 3dk4 by Molmil
Catalytic cycle of human glutathione reductase near 1 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, Glutathione reductase, ...
著者Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A.
登録日2008-06-24
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Catalytic cycle of human glutathione reductase near 1 A resolution.
J.Mol.Biol., 382, 2008
4EC5
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BU of 4ec5 by Molmil
Crystal structure of the S210C (dimer) mutant from the N-terminal domain of the secretin XcpQ from Pseudomonas aeruginosa
分子名称: CALCIUM ION, General secretion pathway protein D
著者Van der Meeren, R, Savvides, S.
登録日2012-03-26
公開日2012-12-05
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.197 Å)
主引用文献New Insights into the Assembly of Bacterial Secretins: STRUCTURAL STUDIES OF THE PERIPLASMIC DOMAIN OF XcpQ FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
8AV2
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BU of 8av2 by Molmil
Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ...
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
1ONF
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BU of 1onf by Molmil
Crystal structure of Plasmodium falciparum Glutathione reductase
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase
著者Sarma, G.N, Savvides, S.N, Becker, K, Schirmer, M, Schirmer, R.H, Karplus, P.A.
登録日2003-02-27
公開日2003-05-06
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Glutathione reductase of the malarial parasite Plasmodium falciparum: Crystal structure and inhibitor development
J.Mol.Biol., 328, 2003
8OSE
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BU of 8ose by Molmil
C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C
分子名称: 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), 1,2-ETHANEDIOL, Chitodextrinase, ...
著者Bloch, Y, Savvides, S.N.
登録日2023-04-18
公開日2023-07-12
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C
To Be Published
3DK9
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BU of 3dk9 by Molmil
Catalytic cycle of human glutathione reductase near 1 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase, SULFATE ION
著者Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A.
登録日2008-06-24
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Catalytic cycle of human glutathione reductase near 1 A resolution.
J.Mol.Biol., 382, 2008
8OE4
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BU of 8oe4 by Molmil
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
著者Bloch, Y, Felix, J, Savvides, S.N.
登録日2023-03-10
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8ODZ
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BU of 8odz by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1).
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
著者Felix, J, Bloch, Y, Savvides, S.N.
登録日2023-03-10
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8OE0
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BU of 8oe0 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2).
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
著者Felix, J, Bloch, Y, Savvides, S.N.
登録日2023-03-10
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8OYE
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BU of 8oye by Molmil
Clostridium perfringens chitinase CP4_3455 E196Q with chitin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitodextrinase, DIMETHYL SULFOXIDE
著者Bloch, Y, Savvides, S.N.
登録日2023-05-04
公開日2023-07-12
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Clostridium perfringens chitinase CP4_3455 E196Q with chitin
To Be Published
8PB1
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BU of 8pb1 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
著者Felix, J, Bloch, Y, Savvides, S.N.
登録日2023-06-08
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
5MJ3
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BU of 5mj3 by Molmil
INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 1
分子名称: ALPHABODY MA12, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ...
著者Desmet, J, Verstraete, K, Bloch, Y, Lorent, E, Wen, Y, Devreese, B, Vandenbroucke, K, Loverix, S, Hettmann, T, Deroo, S, Somers, K, Hendrikx, P, Lasters, I, Savvides, S.N.
登録日2016-11-29
公開日2017-01-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structural Basis Of Il-23 Antagonism By An Alphabody Protein Scaffold.
Nat Commun, 5, 2014
5N2K
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BU of 5n2k by Molmil
Structure of unbound Briakinumab FAb
分子名称: 1,2-ETHANEDIOL, Briakinumab FAb heavy chain, Briakinumab FAb light chain
著者Bloch, Y, Savvides, S.N.
登録日2017-02-07
公開日2018-01-03
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.219 Å)
主引用文献Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48, 2018

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