1TWX

Crystal structure of the thrombin mutant D221A/D222K

Summary for 1TWX

Entry DOI	10.2210/pdb1twx/pdb
Descriptor	Prothrombin, Hirudin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	thrombin, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	34566.56
Authors	Pineda, A.O.,Zhang, E.,Guinto, E.R.,Savvides, S.N.,Tulinsky, A.,Di Cera, E. (deposition date: 2004-07-01, release date: 2005-04-19, Last modification date: 2023-11-15)
Primary citation	Pineda, A.O.,Zhang, E.,Guinto, E.R.,Savvides, S.N.,Tulinsky, A.,Di Cera, E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form Biophys.Chem., 112:253-256, 2004 Cited by PubMed: 15572256 DOI: 10.1016/j.bpc.2004.07.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation