1TWX
Crystal structure of the thrombin mutant D221A/D222K
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Prothrombin | polymer | 28 | 3303.7 | 1 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | Coagulation factor II |
2 | B | Prothrombin | polymer | 259 | 29750.3 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | Coagulation factor II |
3 | C | Hirudin | polymer | 10 | 1291.3 | 1 | UniProt (P28504) In PDB | ||
4 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
5 | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Ala 183 | Asp 595 | engineered mutation |
Lys 185 | Asp 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 34345.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 34566.6 |