1TWX
Crystal structure of the thrombin mutant D221A/D222K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prothrombin | polymer | 28 | 3303.7 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Prothrombin | polymer | 259 | 29750.3 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (C) | Hirudin | polymer | 10 | 1291.3 | 1 | UniProt (P28504) | ||
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F, G (A, B, C) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 183 | Asp 595 | engineered mutation |
| Lys 185 | Asp 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 34345.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 34566.6 |
