8UT2
 
 | | Pre-fusion Measles virus fusion protein complexed with Fab 77 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zyla, D, Saphire, E.O. | | Deposit date: | 2023-10-30 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | A neutralizing antibody prevents postfusion transition of measles virus fusion protein.
Science, 384, 2024
|
|
8UTF
 | |
8UUQ
 | |
5TOI
 | |
5TOH
 | | Crystal Structure of the Marburg Virus VP35 Oligomerization Domain I2 | | Descriptor: | Polymerase cofactor VP35 | | Authors: | Bruhn, J.F, Kirchdoerfer, R.N, Tickle, I.J, Bricogne, G, Saphire, E.O. | | Deposit date: | 2016-10-17 | | Release date: | 2016-11-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal Structure of the Marburg Virus VP35 Oligomerization Domain.
J. Virol., 91, 2017
|
|
5T3T
 | | Ebola virus VP30 CTD bound to nucleoprotein | | Descriptor: | Fusion protein of Nucleoprotein and Minor nucleoprotein VP30, SULFATE ION | | Authors: | Kirchdoerfer, R.N, Moyer, C.L, Abelson, D.M, Saphire, E.O. | | Deposit date: | 2016-08-26 | | Release date: | 2016-09-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis.
Plos Pathog., 12, 2016
|
|
5UQY
 | | Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ... | | Authors: | Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O. | | Deposit date: | 2017-02-08 | | Release date: | 2017-03-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
|
|
5T3W
 | |
4ZTG
 | |
4ZTI
 | |
7K5L
 | | Ebola virus VP40 octameric ring generated by an RNA oligonucleotide | | Descriptor: | HSP RNA oligonucleotide, Matrix protein VP40 | | Authors: | Landeras-Bueno, S, Wasserman, H, Salie, Z.L, Saphire, E.O. | | Deposit date: | 2020-09-17 | | Release date: | 2021-04-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form.
Cell Rep, 35, 2021
|
|
7K5D
 | | Ebola virus VP40 octameric ring generated by a DNA oligonucleotide | | Descriptor: | HSP DNA oligonucleotide, Matrix protein VP40 | | Authors: | Landeras-Bueno, S, Wasserman, H, Salie, Z.L, Saphire, E.O. | | Deposit date: | 2020-09-16 | | Release date: | 2021-04-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form.
Cell Rep, 35, 2021
|
|
5B0V
 | | Crystal Structure of Marburg virus VP40 Dimer | | Descriptor: | ETHANOL, Matrix protein VP40 | | Authors: | Oda, S, Bornholdt, Z.A, Abelson, D.M, Saphire, E.O. | | Deposit date: | 2015-11-05 | | Release date: | 2016-01-20 | | Last modified: | 2016-03-09 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression
J.Virol., 90, 2015
|
|
4ZTA
 | |
3T5Q
 | | 3A structure of Lassa virus nucleoprotein in complex with ssRNA | | Descriptor: | Nucleoprotein, PHOSPHATE ION, RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3'), ... | | Authors: | Hastie, K.M, Liu, T, King, L.B, Ngo, N, Zandonatti, M.A, Woods, V.L, de la Torre, J.C, Saphire, E.O. | | Deposit date: | 2011-07-27 | | Release date: | 2012-01-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3T5N
 | | 1.8A crystal structure of Lassa virus nucleoprotein in complex with ssRNA | | Descriptor: | NICKEL (II) ION, Nucleoprotein, RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3') | | Authors: | Hastie, K.M, Liu, T, King, L.B, Ngo, N, Zandonatti, M.A, Woods, V.L, de la Torre, J.C, Saphire, E.O. | | Deposit date: | 2011-07-27 | | Release date: | 2012-01-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.787 Å) | | Cite: | Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3TCQ
 | | Crystal Structure of matrix protein VP40 from Ebola virus Sudan | | Descriptor: | Matrix protein VP40 | | Authors: | Clifton, M.C, Edwards, T.E, Anderson, V, Atkins, K, Raymond, A, Saphire, E.O, Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2011-08-09 | | Release date: | 2012-10-03 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.
J Infect Dis, 212 Suppl 2, 2015
|
|
3Q7C
 | | Exonuclease domain of Lassa virus nucleoprotein bound to manganese | | Descriptor: | MANGANESE (II) ION, Nucleoprotein, PHOSPHATE ION, ... | | Authors: | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | | Deposit date: | 2011-01-04 | | Release date: | 2011-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3Q7B
 | | Exonuclease domain of Lassa virus nucleoprotein | | Descriptor: | Nucleoprotein, PHOSPHATE ION, ZINC ION | | Authors: | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | | Deposit date: | 2011-01-04 | | Release date: | 2011-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
7SKU
 | | Nipah virus matrix protein in complex with PI(4,5)P2 | | Descriptor: | Matrix protein, SULFATE ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Norris, M.J, Saphire, E.O. | | Deposit date: | 2021-10-21 | | Release date: | 2022-08-24 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.117 Å) | | Cite: | Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization.
Sci Adv, 8, 2022
|
|
7SKS
 | |
7SKT
 | |
7SWD
 | | Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound | | Descriptor: | 1C11 scFv, 1C3 heavy chain, 1C3 light chain, ... | | Authors: | Milligan, J.C, Yu, X, Saphire, E.O. | | Deposit date: | 2021-11-19 | | Release date: | 2022-04-06 | | Last modified: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
|
|
7TN9
 | | Structure of the Inmazeb cocktail and resistance to escape against Ebola virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, GP2, ... | | Authors: | Rayaprolu, V, Fulton, B, Rafique, A, Arturo, E, Williams, D, Hariharan, C, Callaway, H, Parvate, A, Schendel, S.L, Parekh, D, Hui, S, Shaffer, K, Pascal, K.E, Wloga, E, Giordano, S, Copin, R, Franklin, M, Boytz, R.M, Donahue, C, Davey, R, Baum, A, Kyratsous, C.A, Saphire, E.O. | | Deposit date: | 2022-01-20 | | Release date: | 2023-01-25 | | Last modified: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of the Inmazeb cocktail and resistance to Ebola virus escape.
Cell Host Microbe, 31, 2023
|
|
7U9G
 | | Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, RVA122 Fab Heavy Chain, ... | | Authors: | Callaway, H.M, Zyla, D, Larrous, F, Dias de Melo, G, Hastie, K.M, Avalos, R.D, Agarwal, A, Bouhry, H, Corti, D, Saphire, E.O. | | Deposit date: | 2022-03-10 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Sci Adv, 8, 2022
|
|
