8UUQ

Structure of the Measles virus Fusion protein in the pre-fusion conformation with bound [FIP-HRC]2-PEG11

Summary for 8UUQ

• Entry DOI: 10.2210/pdb8uuq/pdb
• EMDB information: 42595
• Related PRD ID: PRD_002539
• Descriptor: Fusion glycoprotein F0, [FIP-HRC]2-PEG11, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: viral protein, glycoprotein, immune system, measles, high-resolution, ectodomain, post-fusion, small molecule, inhibitor, complex
• Biological source: Measles virus strain Ichinose-B95a; More
• Total number of polymer chains: 9
• Total formula weight: 178534.84

Authors

Zyla, D.,Saphire, E.O. (deposition date: 2023-11-01, release date: 2024-07-03, Last modification date: 2024-07-24)

• Primary citation: Zyla, D.S.,Della Marca, R.,Niemeyer, G.,Zipursky, G.,Stearns, K.,Leedale, C.,Sobolik, E.B.,Callaway, H.M.,Hariharan, C.,Peng, W.,Parekh, D.,Marcink, T.C.,Diaz Avalos, R.,Horvat, B.,Mathieu, C.,Snijder, J.,Greninger, A.L.,Hastie, K.M.,Niewiesk, S.,Moscona, A.,Porotto, M.,Ollmann Saphire, E.; A neutralizing antibody prevents postfusion transition of measles virus fusion protein.; Science, 384:eadm8693-eadm8693, 2024; PubMed: 38935733; DOI: 10.1126/science.adm8693

Experimental method

ELECTRON MICROSCOPY (2.34 Å)