3HDE
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![BU of 3hde by Molmil](/molmil-images/mine/3hde) | Crystal structure of full-length endolysin R21 from phage 21 | Descriptor: | Lysozyme | Authors: | Sun, Q, Arockiasamy, A, McKee, E, Caronna, E, Sacchettini, J.C. | Deposit date: | 2009-05-07 | Release date: | 2009-11-03 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Regulation of a muralytic enzyme by dynamic membrane topology. Nat.Struct.Mol.Biol., 16, 2009
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2QZ8
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![BU of 2qz8 by Molmil](/molmil-images/mine/2qz8) | Crystal structure of Mycobacterium tuberculosis Leucine response regulatory protein (LrpA) | Descriptor: | Probable transcriptional regulatory protein | Authors: | Manchi, C.M.R, Gokulan, K, Ioerger, T, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-08-16 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci., 17, 2008
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4G2R
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![BU of 4g2r by Molmil](/molmil-images/mine/4g2r) | Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis | Descriptor: | (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase | Authors: | Reddy, M.C.M, Bruning, J.B, Thurman, C, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-07-12 | Release date: | 2014-02-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrob.Agents Chemother., 58, 2014
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1VRW
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![BU of 1vrw by Molmil](/molmil-images/mine/1vrw) | Crystal structure analysis of plasmodium falciparum enoyl-acyl-carrier-protein reductase with nadh | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ENOYL-ACYL CARRIER REDUCTASE | Authors: | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | Deposit date: | 2005-06-30 | Release date: | 2005-07-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
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1BYA
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![BU of 1bya by Molmil](/molmil-images/mine/1bya) | CRYSTAL STRUCTURES OF SOYBEAN BETA-AMYLASE REACTED WITH BETA-MALTOSE AND MALTAL: ACTIVE SITE COMPONENTS AND THEIR APPARENT ROLE IN CATALYSIS | Descriptor: | BETA-AMYLASE, SULFATE ION | Authors: | Mikami, B, Degano, M, Hehre, E.J, Sacchettini, J.C. | Deposit date: | 1994-01-25 | Release date: | 1994-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis. Biochemistry, 33, 1994
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1BYC
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![BU of 1byc by Molmil](/molmil-images/mine/1byc) | CRYSTAL STRUCTURES OF SOYBEAN BETA-AMYLASE REACTED WITH BETA-MALTOSE AND MALTAL: ACTIVE SITE COMPONENTS AND THEIR APPARENT ROLE IN CATALYSIS | Descriptor: | BETA-AMYLASE, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Mikami, B, Degano, M, Hehre, E.J, Sacchettini, J.C. | Deposit date: | 1994-01-25 | Release date: | 1994-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis. Biochemistry, 33, 1994
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1BYD
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![BU of 1byd by Molmil](/molmil-images/mine/1byd) | CRYSTAL STRUCTURES OF SOYBEAN BETA-AMYLASE REACTED WITH BETA-MALTOSE AND MALTAL: ACTIVE SITE COMPONENTS AND THEIR APPARENT ROLE IN CATALYSIS | Descriptor: | BETA-AMYLASE, SULFATE ION, alpha-D-glucopyranose-(1-4)-2-deoxy-beta-D-arabino-hexopyranose | Authors: | Mikami, B, Degano, M, Hehre, E.J, Sacchettini, J.C. | Deposit date: | 1994-01-25 | Release date: | 1994-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis. Biochemistry, 33, 1994
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1BYB
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![BU of 1byb by Molmil](/molmil-images/mine/1byb) | CRYSTAL STRUCTURES OF SOYBEAN BETA-AMYLASE REACTED WITH BETA-MALTOSE AND MALTAL: ACTIVE SITE COMPONENTS AND THEIR APPARENT ROLE IN CATALYSIS | Descriptor: | BETA-AMYLASE, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Mikami, B, Degano, M, Hehre, E.J, Sacchettini, J.C. | Deposit date: | 1994-01-25 | Release date: | 1994-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis. Biochemistry, 33, 1994
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1DIH
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![BU of 1dih by Molmil](/molmil-images/mine/1dih) | |
3MHA
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![BU of 3mha by Molmil](/molmil-images/mine/3mha) | Crystal structure of LprG from Mycobacterium tuberculosis bound to PIM | Descriptor: | (1S,2R,3R,4S,5R,6S)-2-(alpha-L-allopyranosyloxy)-3,4,5-trihydroxy-6-({6-O-[(1R)-1-hydroxyhexadecyl]-beta-L-gulopyranosyl}oxy)cyclohexyl (2R)-2-{[(1S)-1-hydroxyhexadecyl]oxy}-3-{[(1S,10S)-1-hydroxy-10-methyloctadecyl]oxy}propyl hydrogen (R)-phosphate, Lipoprotein lprG | Authors: | Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2010-04-07 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat.Struct.Mol.Biol., 17, 2010
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4I36
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![BU of 4i36 by Molmil](/molmil-images/mine/4i36) | Crystal Structure of the Bacillus stearothermophilus Phosphofructokinase Mutant D12A | Descriptor: | 6-phosphofructokinase | Authors: | Mosser, R, Reddy, M, Bruning, J.B, Sacchettini, J.C, Reinhart, G.D. | Deposit date: | 2012-11-25 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase. Biochemistry, 52, 2013
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4IR7
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![BU of 4ir7 by Molmil](/molmil-images/mine/4ir7) | Crystal Structure of Mtb FadD10 in Complex with Dodecanoyl-AMP | Descriptor: | 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine, Long chain fatty acid CoA ligase FadD10, MAGNESIUM ION | Authors: | Liu, Z, Wang, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2013-01-14 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. J.Biol.Chem., 288, 2013
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4ISB
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![BU of 4isb by Molmil](/molmil-images/mine/4isb) | |
4JAQ
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![BU of 4jaq by Molmil](/molmil-images/mine/4jaq) | Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones | Descriptor: | 3,5-dioxoicosanoic acid, Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, ... | Authors: | Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2013-02-19 | Release date: | 2013-04-24 | Last modified: | 2013-11-27 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288, 2013
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4JD3
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![BU of 4jd3 by Molmil](/molmil-images/mine/4jd3) | |
4JAT
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![BU of 4jat by Molmil](/molmil-images/mine/4jat) | |
4JAP
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![BU of 4jap by Molmil](/molmil-images/mine/4jap) | |
4JAR
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![BU of 4jar by Molmil](/molmil-images/mine/4jar) | |
3N87
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![BU of 3n87 by Molmil](/molmil-images/mine/3n87) | Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 3 | Descriptor: | (1R,4R,5R)-1,4,5-trihydroxy-3-[3-(phenylcarbonyl)phenyl]cyclohex-2-ene-1-carboxylic acid, 3-dehydroquinate dehydratase | Authors: | Dias, M.V.B, Snee, W.C, Bromfield, K.M, Payne, R, Palaninathan, S.K, Ciulli, A, Howard, N.I, Abell, C, Sacchettini, J.C, Blundell, T.L. | Deposit date: | 2010-05-27 | Release date: | 2011-05-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem.J., 436, 2011
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4I4I
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![BU of 4i4i by Molmil](/molmil-images/mine/4i4i) | Crystal Structure of Bacillus stearothermophilus Phosphofructokinase mutant T156A bound to PEP | Descriptor: | 6-phosphofructokinase, PHOSPHOENOLPYRUVATE | Authors: | Mosser, R, Reddy, M, Bruning, J.B, Sacchettini, J.C, Reinhart, G.D. | Deposit date: | 2012-11-27 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4948 Å) | Cite: | Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase. Biochemistry, 52, 2013
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3OF2
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![BU of 3of2 by Molmil](/molmil-images/mine/3of2) | Crystal structure of InhA_T266D:NADH complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Molle, V, Gulten, G, Vilcheze, C, Veyron-Churlet, R, Zanella-Cleon, I, Sacchettini, J.C, Jacobs Jr, W.R, Kremer, L. | Deposit date: | 2010-08-13 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol.Microbiol., 78, 2010
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4JAO
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![BU of 4jao by Molmil](/molmil-images/mine/4jao) | |
1AIV
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![BU of 1aiv by Molmil](/molmil-images/mine/1aiv) | APO OVOTRANSFERRIN | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OVOTRANSFERRIN | Authors: | Kurokawa, H, Dewan, J.C, Mikami, B, Sacchettini, J.C, Hirose, M. | Deposit date: | 1997-04-28 | Release date: | 1998-04-29 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron J.Biol.Chem., 274, 1999
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3MH8
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![BU of 3mh8 by Molmil](/molmil-images/mine/3mh8) | |
3N59
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![BU of 3n59 by Molmil](/molmil-images/mine/3n59) | Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate | Descriptor: | (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid, 3-dehydroquinate dehydratase, CHLORIDE ION | Authors: | Snee, W.C, Palaninathan, S.K, Sacchettini, J.C, Dias, M.V.B, Bromfield, K.M, Payne, R, Ciulli, A, Howard, N.I, Abell, C, Blundell, T.L, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2010-05-24 | Release date: | 2010-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem.J., 436, 2011
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