4JAR
Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES
Summary for 4JAR
Entry DOI | 10.2210/pdb4jar/pdb |
Related | 4JAO 4JAP 4JAQ 4JAT 4JD3 |
Descriptor | Alpha-pyrone synthesis polyketide synthase-like Pks11 (1 entity in total) |
Functional Keywords | lipid biosynthesis, structural genomics, enzyme function initiative, ketosynthase enzyme, alkylpyrone synthesis, transferase, mycobacterium tuberculosis structural proteomics project, xmtb |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 150724.58 |
Authors | Gokulan, K.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (deposition date: 2013-02-19, release date: 2013-04-24, Last modification date: 2024-02-28) |
Primary citation | Gokulan, K.,O'Leary, S.E.,Russell, W.K.,Russell, D.H.,Lalgondar, M.,Begley, T.P.,Ioerger, T.R.,Sacchettini, J.C. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288:16484-16494, 2013 Cited by PubMed: 23615910DOI: 10.1074/jbc.M113.468892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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