3N59

Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate

Summary for 3N59

• Entry DOI: 10.2210/pdb3n59/pdb
• Related: 1h05 1h0r 1h0s 2dhq
• Descriptor: 3-dehydroquinate dehydratase, CHLORIDE ION, (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid, ... (4 entities in total)
• Functional Keywords: dehydratase, shikimate pathway, lyase, aromatic amino acid biosynthesis, tuberculosis, drug target, 3-dehydroshikimate, structural genomics, tb structural genomics consortium, tbsgc
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 24
• Total formula weight: 448793.87

Authors

Snee, W.C.,Palaninathan, S.K.,Sacchettini, J.C.,Dias, M.V.B.,Bromfield, K.M.,Payne, R.,Ciulli, A.,Howard, N.I.,Abell, C.,Blundell, T.L.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2010-05-24, release date: 2010-07-21, Last modification date: 2023-09-06)

• Primary citation: Dias, M.V.,Snee, W.C.,Bromfield, K.M.,Payne, R.J.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L.; Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.; Biochem.J., 436:729-739, 2011; PubMed: 21410435; DOI: 10.1042/BJ20110002

Experimental method

X-RAY DIFFRACTION (2.52 Å)