7U3G
 
 | | GID4 in complex with compound 67 | | Descriptor: | (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-5-amine, Glucose-induced degradation protein 4 homolog | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.244 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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7U3K
 | | GID4 in complex with compound 89 | | Descriptor: | GLYCEROL, Glucose-induced degradation protein 4 homolog, N-butylglycyl-4-tert-butyl-D-phenylalanyl-3-methoxy-N-methyl-L-phenylalaninamide | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.198 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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7U3I
 | | GID4 in complex with compound 16 | | Descriptor: | 3-{[(5S)-5-methyl-4,5-dihydro-1,3-thiazol-2-yl]amino}phenol, GLYCEROL, Glucose-induced degradation protein 4 homolog | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.991 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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7U3J
 | | GID4 in complex with compound 88 | | Descriptor: | (2S)-2-{[(2S)-2-({N-[(2,4-dimethoxyphenyl)methyl]glycyl}amino)-2-(thiophen-2-yl)acetyl]amino}-N-methyl-4-phenylbutanamide, GLYCEROL, Glucose-induced degradation protein 4 homolog | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.642 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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7UKZ
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4K25
 | | Crystal Structure of yeast Qri7 homodimer | | Descriptor: | CALCIUM ION, Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ... | | Authors: | Neculai, D, Wan, L, Mao, D.Y, Sicheri, F. | | Deposit date: | 2013-04-08 | | Release date: | 2013-05-08 | | Last modified: | 2013-08-07 | | Method: | X-RAY DIFFRACTION (2.88 Å) | | Cite: | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Res., 41, 2013
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5TWG
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5VYK
 | | Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | | Descriptor: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | | Authors: | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | | Deposit date: | 2017-05-25 | | Release date: | 2018-02-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.749 Å) | | Cite: | MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
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5TWH
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5VR3
 | | Crystal structure of the BRS domain of BRAF | | Descriptor: | BRAF, SULFATE ION | | Authors: | Thevakumaran, N, Maisonneuve, P, Kurinov, I, Lavoie, H, Marullo, S.A, Sahmi, M, Jin, T, Therrien, M, Sicheri, F. | | Deposit date: | 2017-05-10 | | Release date: | 2018-02-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.102 Å) | | Cite: | MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
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5TWF
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3BS5
 | | Crystal Structure of hCNK2-SAM/dHYP-SAM Complex | | Descriptor: | Connector enhancer of kinase suppressor of ras 2, Protein aveugle | | Authors: | Rajakulendran, T, Ceccarelli, D.F, Kurinov, I, Sicheri, F. | | Deposit date: | 2007-12-22 | | Release date: | 2008-02-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.
Proc.Natl.Acad.Sci.USA, 105, 2008
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3BQ3
 | | Crystal structure of S. cerevisiae Dcn1 | | Descriptor: | Defective in cullin neddylation protein 1, GLYCEROL | | Authors: | Chou, Y.C, Sicheri, F. | | Deposit date: | 2007-12-19 | | Release date: | 2008-01-29 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation.
Mol.Cell, 29, 2008
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3LJ1
 | | IRE1 complexed with Cdk1/2 Inhibitor III | | Descriptor: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1 | | Authors: | Lee, K.P.K, Sicheri, F. | | Deposit date: | 2010-01-25 | | Release date: | 2010-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.33 Å) | | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3LJ2
 | | IRE1 complexed with JAK Inhibitor I | | Descriptor: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Serine/threonine-protein kinase/endoribonuclease IRE1 | | Authors: | Lee, K.P.K, Sicheri, F. | | Deposit date: | 2010-01-25 | | Release date: | 2010-05-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.33 Å) | | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3LJ0
 | | IRE1 complexed with ADP and Quercetin | | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Lee, K.P.K, Sicheri, F. | | Deposit date: | 2010-01-25 | | Release date: | 2010-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3ENP
 | | Crystal structure of human cgi121 | | Descriptor: | TP53RK-binding protein | | Authors: | Haffani, Y.Z, Ceccarelli, D.F, Neculai, D, Mao, D.Y, Sicheri, F. | | Deposit date: | 2008-09-25 | | Release date: | 2008-11-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
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3MKS
 | | Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 | | Descriptor: | 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ... | | Authors: | Orlicky, S, Sicheri, F, Tyers, M, Tang, X. | | Deposit date: | 2010-04-15 | | Release date: | 2010-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.
Nat.Biotechnol., 28, 2010
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1NEX
 | | Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex | | Descriptor: | CDC4 protein, Centromere DNA-binding protein complex CBF3 subunit D, GLL(TPO)PPQSG | | Authors: | Orlicky, S, Tang, X, Willems, A, Tyers, M, Sicheri, F. | | Deposit date: | 2002-12-12 | | Release date: | 2003-02-18 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Basis for Phosphodependent Substrate Selection and
Orientation by the SCFCdc4 Ubiquitin Ligase
Cell(Cambridge,Mass.), 112, 2003
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1OPS
 | | ICE-BINDING SURFACE ON A TYPE III ANTIFREEZE PROTEIN FROM OCEAN POUT | | Descriptor: | TYPE III ANTIFREEZE PROTEIN | | Authors: | Yang, D.S.C, Hon, W.-C, Bubanko, S, Xue, Y, Seetharaman, J, Hew, C.L, Sicheri, F. | | Deposit date: | 1997-11-17 | | Release date: | 1998-05-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification of the ice-binding surface on a type III antifreeze protein with a "flatness function" algorithm.
Biophys.J., 74, 1998
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1QCF
 | | CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR | | Descriptor: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK | | Authors: | Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. | | Deposit date: | 1999-05-04 | | Release date: | 1999-06-08 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
Mol.Cell, 3, 1999
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1MBY
 | | Murine Sak Polo Domain | | Descriptor: | serine/threonine kinase | | Authors: | Leung, G.C, Hudson, J.W, Kozarova, A, Davidson, A, Dennis, J.W, Sicheri, F. | | Deposit date: | 2002-08-04 | | Release date: | 2002-10-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.
Nat.Struct.Biol., 9, 2002
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1Q8H
 | | Crystal structure of porcine osteocalcin | | Descriptor: | CALCIUM ION, Osteocalcin | | Authors: | Hoang, Q.Q, Sicheri, F, Howard, A.J, Yang, D.S. | | Deposit date: | 2003-08-21 | | Release date: | 2003-11-11 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Bone recognition mechanism of porcine osteocalcin from crystal structure.
Nature, 425, 2003
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1ZVD
 | | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain | | Descriptor: | PHOSPHATE ION, SODIUM ION, Smad ubiquitination regulatory factor 2 | | Authors: | Ogunjimi, A.A, Briant, D.J, Pece-Barbara, N, Le Roy, C, Di Guglielmo, G.M, Kavsak, P, Rasmussen, R.K, Seet, B.T, Sicheri, F, Wrana, J.L. | | Deposit date: | 2005-06-01 | | Release date: | 2005-08-09 | | Last modified: | 2011-09-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain.
Mol.Cell, 19, 2005
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2A19
 | | PKR kinase domain- eIF2alpha- AMP-PNP complex. | | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ... | | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | | Deposit date: | 2005-06-19 | | Release date: | 2005-09-27 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
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