Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 35 件
6YF8
DownloadVisualize
BU of 6yf8 by Molmil
DYRK1A with PST001
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[5-(5-methoxy-1,3-benzothiazol-2-yl)pyridin-3-yl]ethanamide
著者Rothweiler, U.
登録日2020-03-26
公開日2021-04-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.198 Å)
主引用文献DYRK1A with PST001
To Be Published
3OHT
DownloadVisualize
BU of 3oht by Molmil
Crystal Structure of Salmo Salar p38alpha
分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, SULFATE ION, p38a
著者Rothweiler, U, Johnson, K, Engh, R.A.
登録日2010-08-18
公開日2011-06-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation
J.Mol.Biol., 411, 2011
4D1Z
DownloadVisualize
BU of 4d1z by Molmil
CDK2 in complex with a Luciferin derivate
分子名称: (4S)-2-(8-hydroxyquinolin-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, CYCLIN-DEPENDENT KINASE 2
著者Rothweiler, U, Engh, R.A.
登録日2014-05-05
公開日2015-03-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Luciferin and Derivatives as a Dyrk Selective Scaffold for the Design of Protein Kinase Inhibitors.
Eur.J.Med.Chem., 94, 2015
4D1X
DownloadVisualize
BU of 4d1x by Molmil
CDK2 in complex with Luciferin
分子名称: (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, CYCLIN-DEPENDENT KINASE 2
著者Rothweiler, U, Engh, R.A.
登録日2014-05-05
公開日2015-03-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Luciferin and Derivatives as a Dyrk Selective Scaffold for the Design of Protein Kinase Inhibitors.
Eur.J.Med.Chem., 94, 2015
5LFZ
DownloadVisualize
BU of 5lfz by Molmil
T48 deacetylase
分子名称: ArCE4A, NICKEL (II) ION
著者Rothweiler, U.
登録日2016-07-05
公開日2017-08-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.561 Å)
主引用文献Structure and function of a CE4 deacetylase isolated from a marine environment.
PLoS ONE, 12, 2017
5LGC
DownloadVisualize
BU of 5lgc by Molmil
T48 deacetylase with substrate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ArCE4A
著者Rothweiler, U.
登録日2016-07-06
公開日2017-08-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structure and function of a CE4 deacetylase isolated from a marine environment.
PLoS ONE, 12, 2017
5LW3
DownloadVisualize
BU of 5lw3 by Molmil
Azotobacter vinelandii Mannuronan C-5 epimerase AlgE6 A-module
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ...
著者Rothweiler, U.
登録日2016-09-15
公開日2017-10-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Azotobacter vinelandii Mannuronan C-5 epimerase AlgE6 A-module
To Be Published
5A3X
DownloadVisualize
BU of 5a3x by Molmil
DYRK1A in complex with hydroxy benzothiazole fragment
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, N-(5-oxidanyl-1,3-benzothiazol-2-yl)ethanamide
著者Rothweiler, U.
登録日2015-06-03
公開日2016-06-29
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
5A4L
DownloadVisualize
BU of 5a4l by Molmil
DYRK1A IN COMPLEX WITH FLUORO BENZOTHIAZOLE FRAGMENT
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-FLUORANYL-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE
著者Rothweiler, U.
登録日2015-06-10
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
5A4E
DownloadVisualize
BU of 5a4e by Molmil
DYRK1A in complex with methoxy benzothiazole fragment
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, N-(5-methoxy-1,3-benzothiazol-2-yl)ethanamide
著者Rothweiler, U.
登録日2015-06-08
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
5A4Q
DownloadVisualize
BU of 5a4q by Molmil
DYRK1A IN COMPLEX WITH CHLORO BENZOTHIAZOLE FRAGMENT
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, N-(5-CHLORANYL-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE
著者Rothweiler, U.
登録日2015-06-11
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
5A4T
DownloadVisualize
BU of 5a4t by Molmil
DYRK1A IN COMPLEX WITH NITRILE BENZOTHIAZOLE FRAGMENT
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(6-CYANO-3H-1,3-BENZOTHIAZOL-2-YLIDENE)ETHANAMIDE
著者Rothweiler, U.
登録日2015-06-15
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
5A54
DownloadVisualize
BU of 5a54 by Molmil
DYRK1A IN COMPLEX WITH NITRO BENZOTHIAZOLE FRAGMENT
分子名称: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, N-(6-nitro-1,3-benzothiazol-2-yl)ethanamide
著者Rothweiler, U.
登録日2015-06-16
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
J.Med.Chem., 59, 2016
6EIV
DownloadVisualize
BU of 6eiv by Molmil
DYRK1A in complex with JWD-065
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIR
DownloadVisualize
BU of 6eir by Molmil
DYRK1A in complex with XMD15-27-2
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2021-07-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIQ
DownloadVisualize
BU of 6eiq by Molmil
DYRK1A in complex with XMD14-124
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIS
DownloadVisualize
BU of 6eis by Molmil
DYRK1A in complex with JWC-055
分子名称: 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIP
DownloadVisualize
BU of 6eip by Molmil
DYRK1A in complex with XMD8-62e
分子名称: 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EJ4
DownloadVisualize
BU of 6ej4 by Molmil
DYRK1A in complex with XMD7-112
分子名称: 3-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)aniline, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者Rothweiler, U.
登録日2017-09-20
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIL
DownloadVisualize
BU of 6eil by Molmil
DYRK1A in complex with XMD8-49
分子名称: DYRK1A, [3-azanyl-6-(5-azanyl-2-methoxy-phenyl)pyrazin-2-yl]-pyridin-3-yl-methanone
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.465 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIF
DownloadVisualize
BU of 6eif by Molmil
DYRK1A in complex with XMD7-117
分子名称: 4-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIJ
DownloadVisualize
BU of 6eij by Molmil
DYRK1A in complex with HG-8-60-1
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
7WU8
DownloadVisualize
BU of 7wu8 by Molmil
Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1
分子名称: Regulator of telomere elongation helicase 1
著者Kumar, N, Rothweiler, U, Singh, M.
登録日2022-02-07
公開日2023-08-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides insights into its recruitment to DNA repair sites.
Nucleic Acids Res., 52, 2024
6KML
DownloadVisualize
BU of 6kml by Molmil
2.09 Angstrom resolution crystal structure of tetrameric HigBA toxin-antitoxin complex from E.coli
分子名称: Antitoxin HigA, mRNA interferase toxin HigB
著者Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
登録日2019-07-31
公開日2020-11-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.095 Å)
主引用文献2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020
6KMQ
DownloadVisualize
BU of 6kmq by Molmil
2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from E. coli
分子名称: Antitoxin HigA, mRNA interferase toxin HigB
著者Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
登録日2019-07-31
公開日2020-11-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020

 

12>

219869

件を2024-05-15に公開中

PDB statisticsPDBj update infoContact PDBjnumon