6EIP
DYRK1A in complex with XMD8-62e
Summary for 6EIP
| Entry DOI | 10.2210/pdb6eip/pdb |
| Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide (3 entities in total) |
| Functional Keywords | dual specificity tyrosine-phosphorylation-regulated kinase 1a, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 172298.00 |
| Authors | Rothweiler, U. (deposition date: 2017-09-19, release date: 2018-08-29, Last modification date: 2018-09-26) |
| Primary citation | Czarna, A.,Wang, J.,Zelencova, D.,Liu, Y.,Deng, X.,Choi, H.G.,Zhang, T.,Zhou, W.,Chang, J.W.,Kildalsen, H.,Seternes, O.M.,Gray, N.S.,Engh, R.A.,Rothweiler, U. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61:7560-7572, 2018 Cited by PubMed: 30095246DOI: 10.1021/acs.jmedchem.7b01847 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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