6EIR
DYRK1A in complex with XMD15-27-2
Summary for 6EIR
| Entry DOI | 10.2210/pdb6eir/pdb |
| Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide (3 entities in total) |
| Functional Keywords | dual specificity tyrosine-phosphorylation-regulated kinase 1a, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 172594.40 |
| Authors | Rothweiler, U. (deposition date: 2017-09-19, release date: 2018-08-29, Last modification date: 2021-07-07) |
| Primary citation | Czarna, A.,Wang, J.,Zelencova, D.,Liu, Y.,Deng, X.,Choi, H.G.,Zhang, T.,Zhou, W.,Chang, J.W.,Kildalsen, H.,Seternes, O.M.,Gray, N.S.,Engh, R.A.,Rothweiler, U. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61:7560-7572, 2018 Cited by PubMed: 30095246DOI: 10.1021/acs.jmedchem.7b01847 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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