5A4L
DYRK1A IN COMPLEX WITH FLUORO BENZOTHIAZOLE FRAGMENT
Summary for 5A4L
Entry DOI | 10.2210/pdb5a4l/pdb |
Related | 5A3X 5A4E 5A4Q 5A4T 5A54 |
Descriptor | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-FLUORANYL-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 4 |
Total formula weight | 171456.88 |
Authors | Rothweiler, U. (deposition date: 2015-06-10, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Rothweiler, U.,Stensen, W.,Brandsdal, B.O.,Isaksson, J.,Leeson, F.A.,Eugh, R.A.,Mjoen Svendsen, J.S. Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules J.Med.Chem., 59:9814-, 2016 Cited by PubMed: 27736065DOI: 10.1021/ACS.JMEDCHEM.6B01086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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