4RIL
 
 | | Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | | 分子名称: | Alpha-synuclein | | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | | 登録日 | 2014-10-06 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
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5VOS
 | | VGSNKGAIIGL from Amyloid Beta determined by MicroED | | 分子名称: | Amyloid beta A4 protein | | 著者 | Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S, Griner, S.L, Gonen, T. | | 登録日 | 2017-05-03 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.42 Å) | | 主引用文献 | Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
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6WX1
 | | Antigen Binding Fragment of OKT9 | | 分子名称: | GLYCEROL, OKT9 Fab Heavy Chain, OKT9 Fab Light Chain | | 著者 | Rodriguez, J.A, Helguera, G, Sawaya, M, Cascio, D, Collazo, M, Flores, M, Zink, S, Ferrero, S, Payes, C, Fuentes, D, Short, C. | | 登録日 | 2020-05-09 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain.
J.Virol., 95, 2021
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5K2H
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5K2F
 | | Structure of NNQQNY from yeast prion Sup35 with cadmium acetate determined by MicroED | | 分子名称: | ACETATE ION, CADMIUM ION, Eukaryotic peptide chain release factor GTP-binding subunit | | 著者 | Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2016-05-18 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | | 主引用文献 | Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5K2E
 | | Structure of NNQQNY from yeast prion Sup35 with zinc acetate determined by MicroED | | 分子名称: | ACETIC ACID, Eukaryotic peptide chain release factor GTP-binding subunit, ZINC ION | | 著者 | Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2016-05-18 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | | 主引用文献 | Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5K2G
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8QIC
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4ZNN
 | | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | | 分子名称: | Alpha-synuclein | | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | | 登録日 | 2015-05-05 | | 公開日 | 2015-09-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
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1HLK
 | | METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR | | 分子名称: | 7,8-DIHYDROXY-1-METHOXY-3-METHYL-10-OXO-4,10-DIHYDRO-1H,3H-PYRANO[4,3-B]CHROMENE-9-CARBOXYLIC ACID, BETA-LACTAMASE, TYPE II, ... | | 著者 | Payne, D.J, Hueso-Rodriguez, J.A, Boyd, H, Concha, N.O, Janson, C.A, Gilpin, M, Bateson, J.H, Chever, C, Niconovich, N.L, Pearson, S, Rittenhouse, S, Tew, D, Diez, E, Perez, P, de la Fuente, J, Rees, M, Rivera-Sagredo, A. | | 登録日 | 2000-12-01 | | 公開日 | 2001-11-30 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases
Antimicrob.Agents Chemother., 46, 2002
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6M9I
 | | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | 分子名称: | Ice nucleation protein | | 著者 | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | 登録日 | 2018-08-23 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | 主引用文献 | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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8G2V
 | | Cryo-EM structure of recombinant human LECT2 amyloid fibril core | | 分子名称: | Leukocyte cell-derived chemotaxin-2 | | 著者 | Richards, L.S, Flores, M.D, Zink, S, Schibrowsky, N.A, Sawaya, M.R, Rodriguez, J.A. | | 登録日 | 2023-02-06 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.715 Å) | | 主引用文献 | Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core.
Structure, 31, 2023
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6AXZ
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6EEX
 | | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | 分子名称: | L-GSTSTA from ice nucleaction protein, inaZ | | 著者 | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | 登録日 | 2018-08-15 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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8SPA
 | | Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment | | 分子名称: | Cytoplasmic polyadenylation element-binding protein 3 | | 著者 | Flores, M.D, Sawaya, M.R, Boyer, D.R, Zink, S, Fioriti, L, Rodriguez, J.A. | | 登録日 | 2023-05-02 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation
To Be Published
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1UXM
 | | A4V mutant of human SOD1 | | 分子名称: | COPPER (II) ION, SUPEROXIDE DISMUTASE [CU-ZN], ZINC ION | | 著者 | Hough, M.A, Grossmann, J.G, Antonyuk, S.V, Strange, R.W, Doucette, P.A, Rodriguez, J.A, Whitson, L.J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | 登録日 | 2004-02-26 | | 公開日 | 2004-03-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
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1UXL
 | | I113T mutant of human SOD1 | | 分子名称: | COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | | 著者 | Hough, M.A, Grossmann, J.G, Antonyuk, S.V, Strange, R.W, Doucette, P.A, Rodriguez, J.A, Whitson, L.J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | 登録日 | 2004-02-25 | | 公開日 | 2004-03-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
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5V5C
 | | VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-14 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.25 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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5V5B
 | | KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-13 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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5FOZ
 | | De novo structure of the binary mosquito larvicide BinAB at pH 10 | | 分子名称: | LARVICIDAL TOXIN PROTEIN, SODIUM ION, TOXIN | | 著者 | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | | 登録日 | 2015-11-26 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
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5G37
 | | MR structure of the binary mosquito larvicide BinAB at pH 5 | | 分子名称: | 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN | | 著者 | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | | 登録日 | 2016-04-24 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
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8T1N
 | | Micro-ED Structure of a Novel Domain of Unknown Function Solved with AlphaFold | | 分子名称: | DUF1842 domain-containing protein | | 著者 | Miller, J.E, Cascio, D, Sawaya, M.R, Cannon, K.A, Rodriguez, J.A, Yeates, T.O. | | 登録日 | 2023-06-02 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3 Å) | | 主引用文献 | AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography.
Acta Crystallogr D Struct Biol, 80, 2024
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5FOY
 | | De novo structure of the binary mosquito larvicide BinAB at pH 7 | | 分子名称: | 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN | | 著者 | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | | 登録日 | 2015-11-26 | | 公開日 | 2016-10-05 | | 最終更新日 | 2019-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
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6UOS
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6UOW
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