8CN5
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8COV
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8CN8
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8CNG
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8CN2
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8CN4
| Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... | 著者 | Georgiou, C, Brenk, R. | 登録日 | 2023-02-21 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
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8CNE
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6WMP
| F. tularensis RNAPs70-iglA DNA complex | 分子名称: | DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ... | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | 登録日 | 2020-04-21 | 公開日 | 2020-11-11 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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4QQ0
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7QNH
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NADH, AND GLYCEROL | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE (III) ION, GLYCEROL, ... | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
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8B5S
| Crystal Structure of P. aeruginosa WaaG in complex with UDP-glucose | 分子名称: | UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | 登録日 | 2022-09-24 | 公開日 | 2023-10-04 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis. J.Biol.Chem., 299, 2023
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8B5Q
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8B62
| Crystal Structure of P. aeruginosa WaaG in complex with UDP-galactose | 分子名称: | GALACTOSE-URIDINE-5'-DIPHOSPHATE, GLYCEROL, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | 登録日 | 2022-09-25 | 公開日 | 2023-10-04 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis. J.Biol.Chem., 299, 2023
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8B63
| Crystal Structure of P. aeruginosa WaaG in complex with UDP-GalNAc | 分子名称: | ACETATE ION, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, ... | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | 登録日 | 2022-09-25 | 公開日 | 2023-10-04 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis. J.Biol.Chem., 299, 2023
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8PFZ
| Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid | 分子名称: | (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ... | 著者 | Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. | 登録日 | 2023-06-17 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
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8PD1
| Pseudomonas aeruginosa FabF C164A mutant in complex with N-isopropyl-1H-imidazole-4-carboxamide | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. | 登録日 | 2023-06-11 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
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7QNF
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NAD+, AND ETHYLENE GLYCOL | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, FE (III) ION, ... | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | 登録日 | 2021-12-20 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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7QNI
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT L259V | 分子名称: | CITRIC ACID, Lactaldehyde reductase | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | 登録日 | 2021-12-20 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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7QNJ
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT F254I COMPLEXED WITH FE, NAD+, AND GLYCEROL | 分子名称: | FE (III) ION, GLYCEROL, Lactaldehyde reductase, ... | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | 登録日 | 2021-12-20 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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7QLS
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NADH, AND DIMETHOXYPHENYL ACETAMIDE | 分子名称: | 2-(3,4-dimethoxyphenyl)ethanamide, ADENOSINE-5-DIPHOSPHORIBOSE, FE (III) ION, ... | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
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7QLQ
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NAD, AND DIMETHOXYPHENYL ACETAMIDE | 分子名称: | 2-(3,4-dimethoxyphenyl)ethanamide, ACETATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ... | 著者 | Sridhar, S, Kiema, T.R, Widersten, M, Wierenga, R.K. | 登録日 | 2021-12-20 | 公開日 | 2022-12-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
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7QLG
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT L259V COMPLEXED WITH FE, NADH, AND GLYCEROL | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE (III) ION, GLYCEROL, ... | 著者 | Sridhar, S, Kiema, T.R, Widertsen, M, Wierenga, R.K. | 登録日 | 2021-12-20 | 公開日 | 2022-12-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
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7R5T
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT F254I COMPLEXED WITH FE, NADH, AND GLYCEROL | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ADENOSINE-5-DIPHOSPHORIBOSE, FE (III) ION, ... | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R, Widersten, M. | 登録日 | 2022-02-11 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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7R3D
| CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NADH, AND GLYCEROL (Absence of Nicotinamide ring) | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, FE (III) ION, Lactaldehyde reductase | 著者 | Sridhar, S, Kiema, T.R, Wierenga, R, Widersten, M. | 登録日 | 2022-02-07 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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7OC1
| Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with Platensimycin | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Georgiou, C, Brenk, R, Espeland, L.O, Klein, R. | 登録日 | 2021-04-25 | 公開日 | 2021-08-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics. Chemmedchem, 16, 2021
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