8FHW

Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in complex with uridine diphosphate and glucose-6-phosphate

Summary for 8FHW

Entry DOI	10.2210/pdb8fhw/pdb
EMDB information	29172
Descriptor	Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, 6-O-phosphono-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	glycosyltransferase, complex, transferase
Biological source	Cryptococcus neoformans var. grubii H99
Total number of polymer chains	4
Total formula weight	309919.19
Authors	Washington, E.J.,Brennan, R.G. (deposition date: 2022-12-15, release date: 2023-12-20, Last modification date: 2023-12-27)
Primary citation	Washington, E.J.,Zhou, Y.,Hsu, A.L.,Petrovich, M.,Borgnia, M.J.,Bartesaghi, A.,Brennan, R.G. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : a target for novel antifungals. Biorxiv, 2023 Cited by PubMed: 36993618 DOI: 10.1101/2023.03.14.530545 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation