7OC0

Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with a ligand (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid

Summary for 7OC0

Entry DOI	10.2210/pdb7oc0/pdb
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 2, (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	inhibitor, antibiotic, fatty acid biosynthesis pathway
Biological source	Pseudomonas aeruginosa PAO1
Total number of polymer chains	2
Total formula weight	87569.12
Authors	Georgiou, C.,Brenk, R.,Espeland, L.O.,Klein, R. (deposition date: 2021-04-25, release date: 2021-08-25, Last modification date: 2024-01-31)
Primary citation	Espeland, L.O.,Georgiou, C.,Klein, R.,Bhukya, H.,Haug, B.E.,Underhaug, J.,Mainkar, P.S.,Brenk, R. An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics. Chemmedchem, 16:2715-2726, 2021 Cited by PubMed: 34189850 DOI: 10.1002/cmdc.202100302 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation