8CN2

Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide

Summary for 8CN2

• Entry DOI: 10.2210/pdb8cn2/pdb
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: inhibitor, transferase, fabf, complex
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 88698.77

Authors

Georgiou, C.,Brenk, R. (deposition date: 2023-02-21, release date: 2024-01-10)

• Primary citation: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

Experimental method

X-RAY DIFFRACTION (1.88 Å)