6EZM
| Imidazoleglycerol-phosphate dehydratase from Saccharomyces cerevisiae | 分子名称: | Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid | 著者 | Rawson, S, Bisson, C, Hurdiss, D.L, Muench, S.P. | 登録日 | 2017-11-15 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EZJ
| Imidazoleglycerol-phosphate dehydratase | 分子名称: | Imidazoleglycerol-phosphate dehydratase 2, chloroplastic, MANGANESE (II) ION, ... | 著者 | Rawson, S, Bisson, C, Hurdiss, D.L, Muench, S.P. | 登録日 | 2017-11-15 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6Q0K
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-01 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
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6Q0J
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-01 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
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6Q0T
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-02 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
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6V05
| Cryo-EM structure of a substrate-engaged Bam complex | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | 著者 | Tomasek, D, Rawson, S, Lee, J, Wzorek, J.S, Harrison, S.C, Li, Z, Kahne, D. | 登録日 | 2019-11-18 | 公開日 | 2020-06-10 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of a nascent membrane protein as it folds on the BAM complex. Nature, 583, 2020
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6NYB
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Park, E, Rawson, S, Li, K, Jeon, H, Eck, M.J. | 登録日 | 2019-02-11 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
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8DGT
| Cryo-EM structure of a RAS/RAF complex (state 2) | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Eck, M.J, Jeon, H, Park, E, Rawson, S. | 登録日 | 2022-06-24 | 公開日 | 2023-07-05 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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8DGS
| Cryo-EM structure of a RAS/RAF complex (state 1) | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Eck, M.J, Jeon, H, Park, E, Rawson, S. | 登録日 | 2022-06-24 | 公開日 | 2023-07-05 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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7TMW
| Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs | 分子名称: | Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Erlandson, S.C, Rawson, S, Kruse, A.C. | 登録日 | 2022-01-20 | 公開日 | 2023-02-15 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19, 2023
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7TEO
| Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle in complex with FUB1 | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | 著者 | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | 登録日 | 2022-01-05 | 公開日 | 2022-08-10 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat.Struct.Mol.Biol., 29, 2022
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7TEJ
| Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | 著者 | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | 登録日 | 2022-01-05 | 公開日 | 2022-08-10 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat.Struct.Mol.Biol., 29, 2022
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8QYJ
| Human 20S proteasome assembly structure 1 | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome assembly chaperone 3, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QZ9
| Human 20S proteasome assembly intermediate structure 4 | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QYL
| Human 20S proteasome assembly intermediate structure 2 | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QYM
| Human 20S proteasome assembly intermediate structure 3 | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QYN
| Human 20S proteasome assembly intermediate structure 5 | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QYS
| Human preholo proteasome 20S core particle | 分子名称: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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8QYO
| Human proteasome 20S core particle | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | 登録日 | 2023-10-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 31, 2024
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6W8N
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6W8P
| Structure of membrane protein with ions | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | 著者 | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | 登録日 | 2020-03-21 | 公開日 | 2021-08-04 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of membrane protein with ions To Be Published
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6W8O
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8G2Y
| Cryo-EM structure of ADGRF1 coupled to miniGs/q | 分子名称: | Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jones, D, Rawson, S, Blacklow, S. | 登録日 | 2023-02-06 | 公開日 | 2023-05-10 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun, 14, 2023
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8U6Y
| Preholo-Proteasome from Beta 3 D205 deletion | 分子名称: | Proteasome assembly chaperone 2, Proteasome chaperone 1, Proteasome maturation factor UMP1, ... | 著者 | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | 登録日 | 2023-09-14 | 公開日 | 2024-04-17 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of autocatalytic activation during proteasome assembly. Nat.Struct.Mol.Biol., 31, 2024
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8U7U
| Proteasome 20S Core Particle from Beta 3 D205 deletion | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | 登録日 | 2023-09-15 | 公開日 | 2024-04-17 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | 主引用文献 | Mechanism of autocatalytic activation during proteasome assembly. Nat.Struct.Mol.Biol., 31, 2024
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