6EZM

Imidazoleglycerol-phosphate dehydratase from Saccharomyces cerevisiae

Summary for 6EZM

Entry DOI	10.2210/pdb6ezm/pdb
EMDB information	3999 4160
Descriptor	Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid (3 entities in total)
Functional Keywords	inhibitor, histidine biosynthesis, lyase, complex
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Total number of polymer chains	24
Total formula weight	580420.73
Authors	Rawson, S.,Bisson, C.,Hurdiss, D.L.,Muench, S.P. (deposition date: 2017-11-15, release date: 2018-02-07, Last modification date: 2024-05-15)
Primary citation	Rawson, S.,Bisson, C.,Hurdiss, D.L.,Fazal, A.,McPhillie, M.J.,Sedelnikova, S.E.,Baker, P.J.,Rice, D.W.,Muench, S.P. Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 115:1795-1800, 2018 Cited by PubMed: 29434040 DOI: 10.1073/pnas.1708839115 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation