2FE8
 
 | | SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme | | 分子名称: | BROMIDE ION, Replicase polyprotein 1ab, SULFATE ION, ... | | 著者 | Ratia, K, Santarsiero, B.D, Mesecar, A.D. | | 登録日 | 2005-12-15 | | 公開日 | 2006-03-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
8DSM
 | | Human NAMPT in complex with inhibitor ZN-4-3 | | 分子名称: | (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | A structural mechanism for positive allosteric modulation of nicotinamide phosphoribosyltransferase to elevate cellular NAD+
To Be Published
|
|
8F7L
 | | Human NAMPT in complex with substrate NAM and small molecule activator ZN-29-S | | 分子名称: | (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[(2P)-2-(3-fluoro-4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]piperidine-3-carboxamide, CHLORIDE ION, NICOTINAMIDE, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-11-18 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Human NAMPT in complex with substrate NAM and small molecule activator ZN-29-S
To Be Published
|
|
8DSD
 | | Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S | | 分子名称: | (3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.429 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
8DSH
 | | Human NAMPT in complex with quercitrin and AMPcP | | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
8DTJ
 | | Human NAMPT in complex with small molecule activator ZN-43-S | | 分子名称: | (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-25 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
8DSC
 | | Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R | | 分子名称: | (3R)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.321 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
8DSI
 | | Human NAMPT in complex with substrate NAM | | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINAMIDE, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
8DSE
 | | Human NAMPT in complex with substrate NAM and activator quercitrin | | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, CHLORIDE ION, NICOTINAMIDE, ... | | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.428 Å) | | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry, 62, 2023
|
|
2ALV
 | | X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors | | 分子名称: | N-((3S,6R)-6-((S,E)-4-ETHOXYCARBONYL-1-((S)-2-OXOPYRROLIDIN-3-YL)BUT-3-EN-2-YLCARBAMOYL)-2,9-DIMETHYL-4-OXODEC-8-EN-3-YL)-5-METHYLISOXAZOLE-3-CARBOXAMIDE, Replicase polyprotein 1ab | | 著者 | Ghosh, A.K, Xi, K, Ratia, K, Santarsiero, B.D, Fu, W, Harcourt, B.H, Rota, P.A, Baker, S.C, Johnson, M.E, Mesecar, A.D. | | 登録日 | 2005-08-08 | | 公開日 | 2006-08-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.
J.Med.Chem., 48, 2005
|
|
4MM3
 | |
2ZC1
 | | Organophosphorus Hydrolase from Deinococcus radiodurans | | 分子名称: | BROMIDE ION, COBALT (II) ION, Phosphotriesterase | | 著者 | Larsen, S.D, Hawwa, R, Ratia, K, Santarsiero, B.D, Mesecar, A.D. | | 登録日 | 2007-11-02 | | 公開日 | 2008-11-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | X-Ray Structural Insights into a Phosphotriesterase
to be published
|
|
3E9S
 | |
3GTF
 | | D71G/E101G/V235L mutant in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-27 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GU1
 | | Y97W mutant in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, GLYCEROL, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-28 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GTH
 | | D71G/E101G/M234I mutant in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, FORMIC ACID, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-27 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GU2
 | | Y97L/G100-/E101- mutant in organophosphorus hydrolase | | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-28 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GU9
 | | R228A mutation in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-28 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3HTW
 | | Organophosphorus hydrolase from Deinococcus radiodurans with cacodylate bound | | 分子名称: | CACODYLATE ION, COBALT (II) ION, MAGNESIUM ION, ... | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-06-12 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GTI
 | | D71G/E101G/M234L mutant in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase, SODIUM ION | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-27 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
3GTX
 | | D71G/E101G mutant in organophosphorus hydrolase from Deinococcus radiodurans | | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase | | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | | 登録日 | 2009-03-28 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.
J.Mol.Biol., 393, 2009
|
|
