1IMF
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1IMC
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5A32
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![BU of 5a32 by Molmil](/molmil-images/mine/5a32) | Electron cryo-microscopy of Cowpea Mosaic Virus containing RNA-1 (CPMVb) | Descriptor: | RNA2 POLYPROTEIN | Authors: | Hesketh, E.L, Meshcheriakova, Y, Dent, K.C, Saxena, P, Thompson, R, Cockburn, J.J, Lomonossoff, G.P, Ranson, N.A. | Deposit date: | 2015-05-27 | Release date: | 2015-12-23 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM. Nat Commun, 6, 2015
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4UN0
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![BU of 4un0 by Molmil](/molmil-images/mine/4un0) | Crystal structure of the human CDK12-cyclinK complex | Descriptor: | CYCLIN-DEPENDENT KINASE 12, CYCLIN-K | Authors: | Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Chaikuad, A, Goubin, S, Krojer, T, Sorrell, F.J, Nowak, R, Williams, E, Kopec, J, Mahajan, R.P, Burgess-Brown, N, Carpenter, E.P, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2014-05-22 | Release date: | 2014-06-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding. Sci.Rep., 5, 2015
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8G2I
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![BU of 8g2i by Molmil](/molmil-images/mine/8g2i) | Crystal Structure of PRMT4 with Compound YD1290 | Descriptor: | 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-03 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13, 2023
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2DDK
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![BU of 2ddk by Molmil](/molmil-images/mine/2ddk) | Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (orthorhombic form) | Descriptor: | Inositol monophosphatase 2 | Authors: | Arai, R, Ito, K, Kamo-Uchikubo, T, Bessho, Y, Ohba, H, Ohnishi, T, Yoshikawa, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-01-30 | Release date: | 2007-02-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures Proteins, 67, 2007
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8FBP
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![BU of 8fbp by Molmil](/molmil-images/mine/8fbp) | Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation | Descriptor: | Glutamine synthetase | Authors: | Phan, I.Q, Staker, B, Shek, R, Moser, T.H, Evans, J.E, van Voorhis, W.C, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2022-11-29 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation To Be Published
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3ISA
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![BU of 3isa by Molmil](/molmil-images/mine/3isa) | CRYSTAL STRUCTURE OF putative enoyl-CoA hydratase/isomerase FROM Bordetella parapertussis | Descriptor: | CHLORIDE ION, GLYCEROL, Putative enoyl-CoA hydratase/isomerase | Authors: | Patskovsky, Y, Malashkevich, V, Toro, R, Foti, R, Dickey, M, Miller, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-08-25 | Release date: | 2009-09-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | CRYSTAL STRUCTURE OF enoyl-CoA hydratase FROM Bordetella parapertussis To be Published
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5AEQ
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![BU of 5aeq by Molmil](/molmil-images/mine/5aeq) | Neuronal calcium sensor (NCS-1)from Rattus norvegicus | Descriptor: | CALCIUM ION, NEURONAL CALCIUM SENSOR 1, SODIUM ION | Authors: | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | Deposit date: | 2015-01-08 | Release date: | 2015-02-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. J.Biol.Chem., 290, 2015
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8FRT
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![BU of 8frt by Molmil](/molmil-images/mine/8frt) | X-ray crystal structure of the N-terminal region from HCMV US11 binding to HLA-A*02:01 | Descriptor: | GLYCEROL, Unique short US11 glycoprotein, Beta-2-microglobulin, ... | Authors: | Watson, G.M, Berry, R, Rossjohn, J. | Deposit date: | 2023-01-08 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids. Proc.Natl.Acad.Sci.USA, 121, 2024
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4XJP
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![BU of 4xjp by Molmil](/molmil-images/mine/4xjp) | Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead | Descriptor: | 1,2-ETHANEDIOL, 1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... | Authors: | Finzel, B.C, Dai, R. | Deposit date: | 2015-01-08 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. J. Med. Chem., 60, 2017
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8FU4
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![BU of 8fu4 by Molmil](/molmil-images/mine/8fu4) | HCMV US11 peptide binding to HLA-A*02:01 | Descriptor: | Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ... | Authors: | Watson, G.M, Berry, R, Littler, D.R, Rossjohn, J. | Deposit date: | 2023-01-16 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids. Proc.Natl.Acad.Sci.USA, 121, 2024
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8FY0
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![BU of 8fy0 by Molmil](/molmil-images/mine/8fy0) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | Descriptor: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | Authors: | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY1
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![BU of 8fy1 by Molmil](/molmil-images/mine/8fy1) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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4MIV
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![BU of 4miv by Molmil](/molmil-images/mine/4miv) | Crystal Structure of Sulfamidase, Crystal Form L | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Sidhu, N.S, Uson, I, Schreiber, K, Proepper, K, Becker, S, Sheldrick, G.M, Gaertner, J, Kraetzner, R, Steinfeld, R. | Deposit date: | 2013-09-02 | Release date: | 2014-05-14 | Last modified: | 2021-06-02 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA. Acta Crystallogr.,Sect.D, 70, 2014
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8FY2
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![BU of 8fy2 by Molmil](/molmil-images/mine/8fy2) | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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1EZT
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![BU of 1ezt by Molmil](/molmil-images/mine/1ezt) | HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR | Descriptor: | REGULATOR OF G-PROTEIN SIGNALING 4 | Authors: | Moy, F.J, Chanda, P.K, Cockett, M.I, Edris, W, Jones, P.G, Mason, K, Semus, S, Powers, R. | Deposit date: | 2000-05-11 | Release date: | 2001-01-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha. Biochemistry, 39, 2000
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8FBZ
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![BU of 8fbz by Molmil](/molmil-images/mine/8fbz) | Crystal Structure of apo human Glutathione Synthetase Y270E | Descriptor: | GLYCEROL, Glutathione synthetase, SULFATE ION | Authors: | Stanford, S.M, Santelli, E, Sankaran, B, Murali, R, Bottini, N. | Deposit date: | 2022-11-30 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv, 10, 2024
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3IDU
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![BU of 3idu by Molmil](/molmil-images/mine/3idu) | Crystal Structure of the CARDB domain of the PF1109 protein in complex with di-metal ions from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR193A | Descriptor: | MANGANESE (II) ION, Uncharacterized protein | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-07-21 | Release date: | 2009-08-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Northeast Structural Genomics Consortium Target PfR193A To be Published
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1EZY
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![BU of 1ezy by Molmil](/molmil-images/mine/1ezy) | HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR | Descriptor: | REGULATOR OF G-PROTEIN SIGNALING 4 | Authors: | Moy, F.J, Chanda, P.K, Cockett, M.I, Edris, W, Jones, P.G, Mason, K, Semus, S, Powers, R. | Deposit date: | 2000-05-12 | Release date: | 2001-01-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha. Biochemistry, 39, 2000
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5A80
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![BU of 5a80 by Molmil](/molmil-images/mine/5a80) | Crystal structure of human JMJD2A in complex with compound 40 | Descriptor: | 1,2-ETHANEDIOL, 2-[5-[2-(3-methoxyphenyl)ethanoylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, ... | Authors: | Nowak, R, Velupillai, S, Krojer, T, Gileadi, C, Johansson, C, Korczynska, M, Le, D.D, Younger, N, Gregori-Puigjane, E, Tumber, A, Iwasa, E, Pollock, S.B, Ortiz Torres, I, Kopec, J, Tallant, C, Froese, S, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Shoichet, B.K, Fujimori, D.G, Oppermann, U. | Deposit date: | 2015-07-11 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors. J.Med.Chem., 59, 2016
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8FAQ
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8FAW
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1IIU
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3IRS
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![BU of 3irs by Molmil](/molmil-images/mine/3irs) | CRYSTAL STRUCTURE OF UNCHARACTERIZED TIM-BARREL PROTEIN BB4693 FROM Bordetella bronchiseptica | Descriptor: | GLYCEROL, SODIUM ION, SULFATE ION, ... | Authors: | Patskovsky, Y, Malashkevich, V, Toro, R, Foti, R, Dickey, M, Do, J, Sauder, J.M, Raushel, F.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-08-24 | Release date: | 2009-09-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | CRYSTAL STRUCTURE OF UNCHARACTERIZED HYDROLASE FROM Bordetella bronchiseptica To be Published
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